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KABUL, Afghanistan (CNN) -

A Chicago pediatrician who "felt called" to move to Afghanistan to treat children and train physicians was among three Americans killed Thursday at a Kabul hospital by an Afghan guard.

The police guard opened fire on the pediatrician and four others with him at the CURE Hospital's gates, Kabul police said, in violence not unlike the "green-on-blue" attacks in which Afghan security forces fire upon coalition troops.

Two others were killed, and a third person was injured in the hospital attack. A fourth person was unharmed.

Dr. Jerry Umanos practiced medicine in inner-city Chicago before moving to Afghanistan in 2005, according to the U.S. hospital with which he was affiliated, Lawndale Christian Health Center.

"Our family and friends have suffered a great loss and our hearts are aching," his wife, Jan Schuitema, told reporters in Chicago. The doctor and his wife have three children together.

"I know Jerry would also really like everybody to know about his love for the Afghan people, and our love for the Afghan people, and that we don't hold any ill will towards Afghanistan in general, or even the gunman who did this. We don't know what his history is," she said.

Schuitema stressed that her husband's work was an extension of his faith.

"He always had a desire to be the hands and feet of Christ. He was always a light for Christ," she said.

Umanos was connected with Lawndale for more than 25 years, said Dr. Bruce Rowell, the hospital's chief clinical officer.

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U.S. pediatrician killed in Afghanistan