Breakthrough Study Validates Artificial Intelligence as a Novel Biomarker in Predicting Immunotherapy Response – Published in Journal of Clinical…
The JCO is an international, peer-reviewed medical journal published by the American Society of Clinical Oncology (ASCO), with an impact factor (IF) of 44.54. This is the first time that research on AI biomarkers has been published in an international SCI-grade journal of JCO's prestige.
"Immune phenotyping of tumor microenvironment is a logical biomarker for immunotherapy, but objective measurement of such would be extremely challenging," said Professor Tony Mok from the Chinese University of Hong Kong, co-senior author of the journal. "This is the first study that adopted AI technology to define the tumor immune phenotype, and to demonstrate its ability in predicting treatment outcomes of anti-PD-L1 therapy in two large cohorts of patients with advanced non-small cell lung cancer."
Immune checkpoint inhibitors (ICI) are a standard therapy method for advanced NSCLC with programmed death ligand-1 (PD-L1) expression. However, outcomes vary depending on the patient's tumor microenvironment.
Assessing the PD-L1 tumor proportion score (TPS) can bring predictive benefit for patients with high expression (over 50%), who show superior response to ICI therapy over standard chemotherapy. However, ICIs lose their potency in patients with PD-L1 TPS between 1% and 49%, showing outcomes similar to chemotherapy. Therefore, the development of an accuracy-enhanced biomarker to predict ICI response in NSCLC patients with low PD-L1 expression is highly warranted.
While tumor infiltrating lymphocytes (TIL) are promising biomarkers for predicting ICI treatment outcomes apart from PD-L1, clinical application remains challenging as TIL quantification involves a manual evaluation process bound to practical limitations of interobserver bias and intensive labor. Employing AI's superhuman computational capabilities should open new possibilities for the objective quantification of TIL.
To validate immune phenotyping as a complementary biomarker in NSCLC, researchers divided 518 NSCLC patients into three groups based on their tumor microenvironment: inflamed, immune-excluded, and immune-desert. As a result, clinical characteristics based on each immune phenotype group showed statistically significant differences in progression-free survival (PFS) and overall survival (OS).
Furthermore, analysis of NSCLC patients with PD-L1 TPS between 1% and 49% based on their immune phenotype found that the inflamed group showed significantly higher results in objective response rate (ORR) and progression-free survival (PFS), compared to the non-inflamed groups. This shows Lunit SCOPE IO's ability to supplement PD-L1 TPS as a biomarker by accurately predicting immunotherapy response for patients with low PD-L1 TPS.
"Lunit has demonstrated through several abstracts the credibility of Lunit SCOPE IO as a companion diagnostic tool to predict immunotherapy treatment outcomes," said Chan-Young Ock, Chief Medical Officer at Lunit. "This study is a proof-of-concept that compiles all of our past research that elucidates Lunit AI's ability to optimize cancer treatment selection."
Last year, Lunit announced a strategic investment of USD 26 million from Guardant Health, Inc., a leading precision oncology company. Following this major collaboration intended to reshape and innovate the precision oncology landscape, Lunit continues to refine its global position by validating the effectiveness of its AI technology through various studies.
SOURCE Lunit
Read the rest here:
Breakthrough Study Validates Artificial Intelligence as a Novel Biomarker in Predicting Immunotherapy Response - Published in Journal of Clinical...
- Impact of Artificial Intelligence (AI) on Media and Creative Industries - EDMO - March 1st, 2025 [March 1st, 2025]
- 1 Artificial Intelligence (AI) Stock That Could Be Bigger Than Nvidia in 5 Years - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- This Artificial Intelligence (AI) Stock Is Up 15% in 2025 Already. It Is Still a Solid Buy? - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- Can artificial intelligence be the future solution to the enormous challenges and suffering caused by Schizophrenia? - Nature.com - March 1st, 2025 [March 1st, 2025]
- Applications of Artificial Intelligence in Medical Education: A Systematic Review - Cureus - March 1st, 2025 [March 1st, 2025]
- This Artificial Intelligence (AI) Stock Is Up 15% in 2025 Already. It Is Still a Solid Buy? - AOL - March 1st, 2025 [March 1st, 2025]
- Federal Executive Forum Artificial Intelligence Strategies in Government Progress and Best Practices 2025 - Federal News Network - March 1st, 2025 [March 1st, 2025]
- Introduction to Artificial Intelligence for General Surgeons: A Narrative Review - Cureus - March 1st, 2025 [March 1st, 2025]
- How is Artificial Intelligence Affecting Health Care? - Workers Comp Forum - March 1st, 2025 [March 1st, 2025]
- 1 Spectacular Artificial Intelligence (AI) Stock to Buy With $50 Right Now - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- 20+ Advantages and Disadvantages of AI | Pros of Artificial Intelligence - Simplilearn - March 1st, 2025 [March 1st, 2025]
- Prediction: This Top Artificial Intelligence (AI) Stock Will Start Skyrocketing After March 6 - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- 1 Surprising Stock Harnessing the Power of Artificial Intelligence (AI) - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- 2 Top Artificial Intelligence (AI) Stocks to Buy On the Dip Amid Nasdaq Selloff - Yahoo Finance - March 1st, 2025 [March 1st, 2025]
- Review: Artificial intelligence is shaping the future of diabetes care - News-Medical.Net - March 1st, 2025 [March 1st, 2025]
- Prediction: This Artificial Intelligence (AI) Stock -- a 1,020% Gainer Since Its IPO -- Won't Split Its Stock in 2025. Here's Why - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- A Nobel laureate on the economics of artificial intelligence - MIT Technology Review - March 1st, 2025 [March 1st, 2025]
- Prediction: This Top Artificial Intelligence (AI) Stock Will Start Skyrocketing After March 6 - Nasdaq - March 1st, 2025 [March 1st, 2025]
- Meta Platforms Just Caused This Crucial Artificial Intelligence (AI) Stock to Plummet. Should You Buy the Dip? - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- Artificial Intelligence - AI Update, February 28, 2025: AI News and Views From the Past Week - MarketingProfs.com - March 1st, 2025 [March 1st, 2025]
- The Ultimate Artificial Intelligence (AI) ETF to Buy With $50 Right Now - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- Prediction: This Artificial Intelligence (AI) Company Will Split Its Stock in 2025 - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- Should You Forget Nvidia and Buy 2 Artificial Intelligence (AI) Stocks Instead? - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- Why Artificial Intelligence Stocks SoundHound AI, IonQ, and C3.ai Are Struggling Today - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- 2 Top Artificial Intelligence (AI) Stocks Ready for a Bull Run - The Motley Fool - March 1st, 2025 [March 1st, 2025]
- AI Cant Do This Anymore: The Dangers of Artificial Intelligence in Academia - Skidmore News - March 1st, 2025 [March 1st, 2025]
- Whats Next in Artificial Intelligence: Agents that can do more than chatbots - Pittsburgh Post-Gazette - February 9th, 2025 [February 9th, 2025]
- Geopolitics of artificial intelligence to be focus of major summit in Paris; AP explains - Yahoo - February 9th, 2025 [February 9th, 2025]
- Geopolitics of artificial intelligence to be focus of major summit in Paris; AP explains - The Associated Press - February 9th, 2025 [February 9th, 2025]
- 3 Top Artificial Intelligence Stocks to Buy in February - MSN - February 9th, 2025 [February 9th, 2025]
- Geopolitics of artificial intelligence to be focus of major summit in Paris; AP explains - Lufkin Daily News - February 9th, 2025 [February 9th, 2025]
- 2 of the Hottest Artificial Intelligence (AI) Stocks on the Planet Can Plunge Up to 94%, According to Select Wall Street Analysts - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- These 2 Stocks Are Leading the Data Center Artificial Intelligence (AI) Trend, but Are They Buys Right Now? - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Book Review | Genesis: Artificial Intelligence, Hope, and the Human Spirit - LSE - February 9th, 2025 [February 9th, 2025]
- The Artificial Intelligence Action Summit In France: Maintaining The Dialogue On Global AI Regulation - Forrester - February 9th, 2025 [February 9th, 2025]
- Is prediction the next frontier for artificial intelligence? - Healthcare IT News - February 9th, 2025 [February 9th, 2025]
- The Artificial Intelligence in Medicines Market Is Set to Reach $18,119 Million | CAGR of 49.6% - openPR - February 9th, 2025 [February 9th, 2025]
- Geopolitics of artificial intelligence to be focus of major summit in Paris; AP explains - The Audubon County Advocate Journal - February 9th, 2025 [February 9th, 2025]
- Around and About with Richard McCarthy: Asking AI about itself: Will artificial intelligence ever surpass humankind? - GazetteNET - February 9th, 2025 [February 9th, 2025]
- Will the Paris artificial intelligence summit set a unified approach to AI governanceor just be another conference? - Bulletin of the Atomic... - February 9th, 2025 [February 9th, 2025]
- Apple Stock Jumps on Artificial Intelligence (AI) Driving iPhone Sales. Here's Why It's Not Getting Crushed by the DeepSeek Launch. - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Who will win the race to Artificial General Intelligence? - The Indian Express - February 9th, 2025 [February 9th, 2025]
- Prediction: This Artificial Intelligence (AI) Chip Stock Will Win Big From DeepSeek's Feat - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Prediction: 2 Artificial Intelligence (AI) Stocks That Will Be Worth More Than Nvidia 3 Years From Now - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- State of Louisiana Launches Innovation Brand, Announces Creation of $50 Million Growth Fund and Artificial Intelligence Research Institute - Louisiana... - February 9th, 2025 [February 9th, 2025]
- Using smart technologies and artificial intelligence in food packaging can reduce food waste - Yahoo News Canada - February 9th, 2025 [February 9th, 2025]
- BigBear.ai Wins Department of Defense Contract to Prototype Near-Peer Adversary Geopolitical Risk Analysis for Chief Digital and Artificial... - February 9th, 2025 [February 9th, 2025]
- Should Investors Change Their Artificial Intelligence (AI) Investment Strategy After the DeepSeek Launch? - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- 1 Unstoppable Artificial Intelligence (AI) Stock to Buy Before It Punches Its Ticket to the $4 Trillion Club - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Got 10 Years and $1000? These 3 Artificial Intelligence (AI) Stocks Are Set to Soar. - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- 1 Artificial Intelligence (AI) Stock Down 33% to Buy Hand Over Fist, According to Wall Street - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Rihanna Calls Out Use of Artificial Intelligence on Her Voice to Doctor a Clip of Her Speaking - Billboard - February 9th, 2025 [February 9th, 2025]
- 3 Best Artificial Intelligence (AI) Stocks to Buy in February - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Buying This Top Artificial Intelligence (AI) Stock Looks Like a No-Brainer Right Now - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Is Arm Stock a Buy After the Artificial Intelligence (AI) Chip Designer Released Its Quarterly Earnings Report? - The Motley Fool - February 9th, 2025 [February 9th, 2025]
- Artificial Intelligence, the Academy, And A New Studia Humanitatis - Minding The Campus - February 9th, 2025 [February 9th, 2025]
- The Trump Administrations Artificial Intelligence Rollback Is a Chance to Rethink AI Policy - Ms. Magazine - February 5th, 2025 [February 5th, 2025]
- Workday layoffs: California-based company lays off 1,750 employees, 8.5% of its workforce in favor of artificial intelligence - ABC7 Los Angeles - February 5th, 2025 [February 5th, 2025]
- It can really transform lives: Navigating the ethical landscape of artificial intelligence - WKMG News 6 & ClickOrlando - February 5th, 2025 [February 5th, 2025]
- Legal Restrictions Governing Artificial Intelligence in the Workplace - Law.com - February 5th, 2025 [February 5th, 2025]
- Google drops AI weapons banwhat it means for the future of artificial intelligence - VentureBeat - February 5th, 2025 [February 5th, 2025]
- MPs to scrutinise use of artificial intelligence in the finance sector - ComputerWeekly.com - February 5th, 2025 [February 5th, 2025]
- Catalyzing Change: Innovation and Efficiency through Artificial Intelligence in Contracting - United States Army - February 5th, 2025 [February 5th, 2025]
- STSD to hear cost breakdown, address artificial intelligence in education - The Wellsboro Gazette - February 5th, 2025 [February 5th, 2025]
- OECD activities during the Artificial Intelligence (AI) Action Summit - OECD - February 5th, 2025 [February 5th, 2025]
- Tether Ventures Into Artificial Intelligence With New Application Suite - Bitcoin.com News - February 5th, 2025 [February 5th, 2025]
- Will Artificial Intelligence Kill Acting? Nicholas Cage Thinks It Could - Movieguide - February 5th, 2025 [February 5th, 2025]
- 3 Reasons to Buy This Artificial Intelligence (AI) Stock on the Dip - The Motley Fool - February 5th, 2025 [February 5th, 2025]
- 1 No-Brainer Artificial Intelligence (AI) Stock to Buy With $35 and Hold for the Long Run - The Motley Fool - February 5th, 2025 [February 5th, 2025]
- Google renounces its promise not to develop weapons with artificial intelligence - Mezha.Media - February 5th, 2025 [February 5th, 2025]
- DeepSeek Just Changed Generative Artificial Intelligence (AI) Forever. 2 Surprising Winners From Its Innovation. - The Motley Fool - February 5th, 2025 [February 5th, 2025]
- FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare - The BMJ - February 5th, 2025 [February 5th, 2025]
- DeepSeek Just Exposed the Biggest Flaw of the Artificial Intelligence (AI) Revolution - The Motley Fool - February 5th, 2025 [February 5th, 2025]
- Artificial Intelligence Is Here: How The Innovative Technology Is Taking Over The Stateline - WREX.com - February 5th, 2025 [February 5th, 2025]
- The Ultimate Artificial Intelligence (AI) Stocks to Buy in 2025 - The Motley Fool - February 5th, 2025 [February 5th, 2025]
- This Magnificent Artificial Intelligence (AI) Stock Has Shot Up Over 175% in Just 3 Months, and It Could Soar Higher in 2025 - The Motley Fool - February 5th, 2025 [February 5th, 2025]
- Artificial intelligence is bringing nuclear power back from the dead maybe even in California - CalMatters - February 5th, 2025 [February 5th, 2025]
- Got $5,000? These Are 3 of the Cheapest Artificial Intelligence Stocks to Buy Right Now - The Motley Fool - February 5th, 2025 [February 5th, 2025]
- Compass Capital partners with MIT Sloan School of Management on an artificial intelligence project - ZAWYA - February 5th, 2025 [February 5th, 2025]
- 3 No-Brainer Artificial Intelligence (AI) Stocks to Buy With $500 Right Now - The Motley Fool - February 5th, 2025 [February 5th, 2025]