Archive for the ‘Artificial Intelligence’ Category

Biomonitoring and precision health in deep space supported by … – Nature.com

Afshinnekoo, E. et al. Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration. Cell 183, 11621184 (2020).

Article Google Scholar

Loftus, D. J., Rask, J. C., McCrossin, C. G. & Tranfield, E. M. The chemical reactivity of lunar dust: from toxicity to astrobiology. Earth Moon Planets 107, 95105 (2010).

Article Google Scholar

Pohlen, M., Carroll, D., Prisk, G. K. & Sawyer, A. J. Overview of lunar dust toxicity risk. NPJ Microgravity 8, 55 (2022).

Article Google Scholar

Paul, A.-L. & Ferl, R. J. The biology of low atmospheric pressureimplications for exploration mission design and advanced life support. Gravit. Space Res. 19, 317 (2005).

Council, N. R. Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era (National Academies Press, 2011).

Goswami, N. et al. Maximizing information from space data resources: a case for expanding integration across research disciplines. Eur. J. Appl. Physiol. 113, 16451654 (2013).

Article Google Scholar

McGuire, K. et al. Using systems engineering to develop an integrated crew health and performance system to mitigate risk for human exploration missions. In Proc. 50th International Conference on Environmental Systems, 298, 111 (2021).

Antonsen, E., Hanson, A., Shah, R., Reed, R. D. & Canga, M. A. Conceptual drivers for an exploration medical system. In Proc. 67th International Astronautical Congress 110 (NASA Technical Reports Server, 2016).

Zhao, K. & Zhang, Q. Network protocol architectures for future deep-space internetworking. Sci. China Inf. Sci. 61, 040303 (2018).

Article MathSciNet Google Scholar

Beaton, K. H. et al. Extravehicular activity operations concepts under communication latency and bandwidth constraints. In Proc. 2017 IEEE Aerospace Conference 120 (IEEE, 2017)

Ball, J. R. & Evans, C. H. Jr. Safe Passage: Astronaut Care for Exploration Missions (National Academies Press, 2014).

Google Scholar

Antonsen, E. L. et al. Estimating medical risk in human spaceflight. NPJ Microgravity 8, 8 (2022).

Article Google Scholar

McNulty, M. J. et al. Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry. Front. Microbiol. 12, 700863 (2021).

Article Google Scholar

Blue, R. S. et al. Challenges in clinical management of radiation-induced illnesses during exploration spaceflight. Aerosp. Med. Hum. Perform. 90, 966977 (2019).

Article Google Scholar

Chancellor, J. C. et al. Limitations in predicting the space radiation health risk for exploration astronauts. NPJ Microgravity 4, 8 (2018).

Article Google Scholar

Patel, Z. S. et al. Red risks for a journey to the red planet: the highest priority human health risks for a mission to Mars. NPJ Microgravity 6, 33 (2020).

Article Google Scholar

Jordan, M. I. & Mitchell, T. M. Machine learning: trends, perspectives and prospects. Science 349, 255260 (2015).

Article MathSciNet MATH Google Scholar

Costes, S. V., Sanders, L. M. & Scott, R. T. Workshop on Artificial Intelligence & Modeling for Space Biology https://zenodo.org/record/7508535#.Y9LwQITP23A (2023).

Hood, L. & Flores, M. A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. N. Biotechnol. 29, 613624 (2012).

Article Google Scholar

Zitnik, M. et al. Machine learning for integrating data in biology and medicine: principles, practice and opportunities. Inf. Fusion 50, 7191 (2019).

Article Google Scholar

Sanders, L. M. et al. Biological research and self-driving labs in deep space supported by artificial intelligence. Nat. Mach. Intell. https://doi.org/10.1038/s42256-023-00618-4 (2023).

Kahn, J., Liverman, C. T. & McCoy, M. A. Health Standards for Long Duration and Exploration Spaceflight: Ethics Principles, Responsibilities and Decision Framework (National Academies Press, 2014).

Schmidt, M. A., Schmidt, C. M., Hubbard, R. M. & Mason, C. E. Why personalized medicine is the frontier of medicine and performance for humans in space. New Space 8, 6376 (2020).

Article Google Scholar

National Research Council (US) Committee on A Framework for Developing a New Taxonomy of Disease. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease (National Academies Press, 2012).

Park, S.-M., Ge, T. J., Won, D. D., Lee, J. K. & Liao, J. C. Digital biomarkers in human excreta. Nat. Rev. Gastroenterol. Hepatol. 18, 521522 (2021).

Article Google Scholar

Gambhir, S. S., Ge, T. J., Vermesh, O. & Spitler, R. Toward achieving precision health. Sci. Transl. Med. 10, eaao3612 (2018).

Article Google Scholar

Gambhir, S. S., Ge, T. J., Vermesh, O., Spitler, R. & Gold, G. E. Continuous health monitoring: an opportunity for precision health. Sci. Transl. Med. 13, eabe5383 (2021).

Article Google Scholar

Antonsen, E. L. & Reed, R. D. Policy considerations for precision medicine in human spaceflight. Hous. J. Health L. Policy 19, 137 (2020).

Schork, N. J. Personalized medicine: time for one-person trials. Nature 520, 609611 (2015).

Article Google Scholar

Arges, K. et al. The Project Baseline Health Study: a step towards a broader mission to map human health. NPJ Digit. Med. 3, 84 (2020).

Article Google Scholar

Chen, R. et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 148, 12931307 (2012).

Article Google Scholar

Li, X. et al. Digital health: tracking physiomes and activity using wearable biosensors reveals useful health-related information. PLoS Biol. 15, e2001402 (2017).

Article Google Scholar

Zhou, W. et al. Longitudinal multi-omics of host-microbe dynamics in prediabetes. Nature 569, 663671 (2019).

Article Google Scholar

Mias, G. I. et al. Longitudinal saliva omics responses to immune perturbation: a case study. Sci. Rep. 11, 710 (2021).

Article Google Scholar

Haney, N. M., Urman, A., Waseem, T., Cagle, Y. & Morey, J. M. AIs role in deep space. J. Med. Artif. Intell. 3, 11 (2020).

Article Google Scholar

Yu, K.-H., Beam, A. L. & Kohane, I. S. Artificial intelligence in healthcare. Nat. Biomed. Eng. 2, 719731 (2018).

Article Google Scholar

Topol, E. J. Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again (Basic Books, 2019).

Topol, E. J. High-performance medicine: the convergence of human and artificial intelligence. Nat. Med. 25, 4456 (2019).

Article Google Scholar

Garrett-Bakelman, F. E. et al. The NASA Twins Study: a multidimensional analysis of a year-long human spaceflight. Science 364, eaau8650 (2019).

Article Google Scholar

Thompson, D. E. Space TechnologyGame Changing Development NASA Facts: Autonomous Medical Operations. NASA Technology Reports Server (NASA, 2018).

Walton, M. E. & Kerstman, E. L. Quantification of medical risk on the International Space Station using the Integrated Medical Model. Aerosp. Med. Hum. Perform. 91, 332342 (2020).

Article Google Scholar

Sipes, W., Holland, A. & Beven, G. in Handbook of Bioastronautics (eds Young, L. R. & Sutton, J. P.) 425436 (Springer, 2021).

McGregor, C. A platform for real-time space health analytics as a service utilizing space data relays. In Proc. 2021 IEEE Aerospace Conference (50100) 114 (IEEE, 2021).

McGregor, C. A platform for real-time online health analytics during spaceflight. In Proc. 2013 IEEE Aerospace Conference 18 (IEEE, 2013).

Mindock, J. et al. Systems engineering for space exploration medical capabilities. In Proc. AIAA SPACE and Astronautics Forum and Exposition 139, 306312 (American Institute of Aeronautics and Astronautics, 2017).

Schneider, W. F. et al. NASA environmental control and life support technology development and maturation for exploration: 2019 to 2020 overview. In Proc. International Conference on Environmental Systems 200, 112 (2021).

Broyan, J. L., Shaw, L., Mc Kinley, M., Meyer, C. & Ewert, M. K. NASA environmental control and life support technology development for exploration: 2020 to 2021 overview. In Proc. 50th International Conference on Environmental Systems 384, 112 (NASA, 2021).

Williams-Byrd, J. A. et al. Implementing NASAs capability-driven approach: insight into NASAs processes for maturing exploration systems. In AIAA SPACE 2015 Conference and Exposition (American Institute of Aeronautics and Astronautics, 2015).

Goel, N. & Dinges, D. F. Predicting risk in space: genetic markers for differential vulnerability to sleep restriction. Acta Astronaut. 77, 207213 (2012).

Article Google Scholar

Limkakeng, A. T. Jr. et al. Systematic molecular phenotyping: a path toward precision emergency medicine? Acad. Emerg. Med. 23, 10971106 (2016).

Article Google Scholar

Clment, G. R. et al. Challenges to the central nervous system during human spaceflight missions to Mars. J. Neurophysiol. 123, 20372063 (2020).

Article Google Scholar

Fitzgerald, J. et al. Future of biomarker evaluation in the realm of artificial intelligence algorithms: application in improved therapeutic stratification of patients with breast and prostate cancer. J. Clin. Pathol. 74, 429434 (2021).

Article Google Scholar

Weiss, J., Hoffmann, U. & Aerts, H. J. W. L. Artificial intelligence-derived imaging biomarkers to improve population health. Lancet Digit. Health 2, e154e155 (2020).

Article Google Scholar

Strangman, G. E. et al. Deep-space applications for point-of-care technologies. Curr. Opin. Biomed. Eng. 11, 4550 (2019).

Article Google Scholar

Budd, S. et al. Prototyping CRISP: a Causal Relation and Inference Search Platform applied to colorectal cancer data. In Proc. IEEE 3rd Global Conference on Life Sciences and Technologies (LifeTech) 517521 (IEEE, 2021).

Schmidt, M. A. & Goodwin, T. J. Personalized medicine in human space flight: using Omics based analyses to develop individualized countermeasures that enhance astronaut safety and performance. Metabolomics 9, 11341156 (2013).

Article Google Scholar

Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P. & Tagle, D. A. Organs-on-chips: into the next decade. Nat. Rev. Drug Discov. 20, 345361 (2021).

Article Google Scholar

Tissue Chips in Space https://ncats.nih.gov/tissuechip/projects/space (NIH, 2016).

Yeung, C. K. et al. Tissue chips in spacechallenges and opportunities. Clin. Transl. Sci. 13, 810 (2020).

Article Google Scholar

Papalexi, E. & Satija, R. Single-cell RNA sequencing to explore immune cell heterogeneity. Nat. Rev. Immunol. 18, 3545 (2018).

Article Google Scholar

Gertz, M. L. et al. Multi-omic, single-cell, and biochemical profiles of astronauts guide pharmacological strategies for returning to gravity. Cell Rep. 33, 108429 (2020).

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Biomonitoring and precision health in deep space supported by ... - Nature.com

As per the "Trust in Artificial Intelligence" study, 42% individuals fear … – Digital Information World

Artificial intelligence (AI) has proven helpful to the world in many ways, including the assistants and robots that have taken on many of the tasks associated with daily life and replaced humans in surgical procedures and other professions. Several AI models and tools that are immediately in front of our eyes are ensuring that the world will be a better place, so it's not just the robots that have a beneficial influence on humans, there are models including ChatGPT and Dall-E that have revolutionized the tech industry.

For those who may not be aware, ChatGPT is a chatbot that was introduced in November of 2022. It was created to help users with a variety of tasks. Another significant tech company, "Dell-E," is utilized to produce lifelike images only from a description. They were both created by a business named "OpenAI."

Yet, we are fully aware that it is always bad along with good, therefore to learn more about how people see artificial intelligence, a study titled "Trust in Artificial Intelligence" was conducted during September and October 2022. The University of Queensland and KGPM Australia conducted the study and provided the data on which it was based. A total of 17,193 respondents from seventeen different nations participated in the survey.

There were three separate sections in the survey's poll: "agree," "disagree," and "neutral." Despite everything that has been said about how AI has helped humanity, some individuals still believe that the world would be a far better place without it. 42% of respondents, or two out of every five, agreed with this statement.

What may be the cause of it, then? Several individuals are concerned about their occupations and careers being replaced by AI robots that resemble humans as a result of the study. While 39% of individuals polled denied that AI can take over their future, it's likely that they still believe that some jobs couldn't be replaced by it or that they aren't aware of how rapidly AI's value is increasing. The poll also found that 19% of respondents had a neutral opinion on the matter.

Nonetheless, each person sees the world from a unique perspective. According to the poll, 67% of respondents remain hopeful and upbeat about the future of AI. Even if they are aware of all the negative effects and how they will affect us, some people (57%) are still relaxed about it.

Furthermore, 47% of people report feeling extremely nervous because they fear AI would progressively destroy the human world and that there are very significant risks associated with using AI in daily life, which is not surprising. Also, 24% of them express an angry sentiment against AI and its applications.

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As per the "Trust in Artificial Intelligence" study, 42% individuals fear ... - Digital Information World

Artificial intelligence models aim to forecast eviction, promote renter … – Pennsylvania State University

UNIVERSITY PARK, Pa. Two artificial intelligence-driven models designed by researchers from the Penn State College of Information Sciences and Technology could help promote the rights of low-income renters in the United States when facing forced eviction. Both models aim to forecast where and how many renters could be at risk of eviction to help better inform policymaking and resource allocation.

The researchers first model, "Weakly-supervised Aid to Relieve Nationwide Eviction Rate," helps to identify areas where there could be a high concentration of individuals facing eviction. To identify these hotspots, their framework uses sociological data such as renters educational and financial characteristics that are historically associated with housing instability to label satellite data based on certain features in each image, such as the presence of trees and signs of gentrification. This data is used to train a machine learning model, which identifies eviction filing hotspots in other locations.

Not all states make data on housing instability and eviction rates available, and there is a high cost to collect this data when its even available, said Amulya Yadav, PNC Career Development Assistant Professor and co-author on the study. Our model presents a novel approach by using other data points related to eviction filings to create more efficient and accurate reporting that is highly generalizable to different counties across the country.

The second model, Multi-view model forecasting the number of tenants at-risk of formal eviction," aims to provide an accurate forecast of tenants at-risk of eviction at a certain point in the future.

In a similar approach, the model uses data from available eviction filing records, the U.S. Census American Community Survey, and labor and employment statistics to estimate the number of tenants who may face eviction in each census tract.

Through a collaboration with the Child Poverty Action Lab, a leading non-profit leveraging data-driven approaches to inform actions for relieving poverty-related issues across Dallas County, Texas, the team tested both models against a real-world dataset in that county, where eviction records are more complete and readily available. The models proved to be more accurate than existing baseline models, outperforming some by up to 36%.

There are resources available to help renters facing housing instability, but they are allocated with tremendous variability and sometimes theyre not used at all, said Maryam Tabar, doctoral student and lead author on the study. There is a need to use these funds and resources more efficiently, which is possible through more accurate forecasting of potential evictions.

The team presented the "Weakly-supervised Aid to Relieve Nationwide Eviction Rate" model at the 31st ACM International Conference on Information and Knowledge Management and the multi-view model forecasting the number of tenants at-risk of formal eviction at the 31st International Joint Conference on Artificial Intelligence late last year.

Both models are being evaluated by subject matter experts for a pilot deployment in the field. The team said they hope they can assist non-government organizations and policymakers in making more data-driving decisions about where to allocate resources to better address housing instability, as well as support advocacy efforts with elected officials and agencies related to housing instability.

Eviction disproportionately impacts individuals from underrepresented backgrounds and can exacerbate existing societal problems related to income disparity, educational attainment, and mental health, said Dongwon Lee, professor and co-author on the study. These models can help us better address these challenges and improve the lives of those vulnerable to eviction.

Additional contributors to the projects include doctoral candidate Wooyong Jung at Penn State College of Information Sciences and Technology, as well as Owen Wilson Chavez and Ashley Flores of The Child Poverty Action Lab. The work was supported in part by the National Science Foundation and the Bill and Melinda Gates Foundation.

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Artificial intelligence models aim to forecast eviction, promote renter ... - Pennsylvania State University

How legal departments can get the most out of artificial intelligence – Wolters Kluwer

This article by Abhishek Mittal, vice president of data and operational excellence at Wolters Kluwer,was originally published in Legal Dive.

Artificial intelligence (AI) is changing workflows in every corner of the businessand legal departments are no exception.

The term artificial intelligence was coined by computer scientist John McCarthy about 60 years ago.

Since then, AI has become one of the most promising technological innovations in the corporate world and beyond. Google CEO Sundar Pichai has even suggested that AI may be more impactful than the discovery of fire or the invention of electricity.

Much like a fire, though, AI doesnt keep burning on its own. Someone must build and train it. Thats why, a decade ago, Harvard Business Review declared data scientist the sexiest job of the 21st century.

Having worked with many brilliant data scientists, I find the job title to be a bit of a misnomer. To start, successful AI solutions require the right mix of design, data, and domain expertise.

Data scientists on their own cannot build AI models, just as AI models on their own cannot handle all decision-making. Thats why I refer to data scientists as decision scientists. Even with the advent of AI, decision-making is still in human hands at the end of the day.

Lets take a closer look at what that means in practice and how corporate legal departments can get the most out of the technology.

One of the biggest misperceptions about artificial intelligence is that it is going to replace people, which is simply not the case. Instead, legal professionals who use AI will replace legal professionals who do not.

Think of AI as an enabler, akin to the technology in smart cars. The car cannot drive itself, but it can help with specific tasks like backing up, parking, or changing lanes.

In the future, AI will be as ubiquitous as Microsoft Excel. But decision-making and review processes will still require validation by a human end user.

When my company was designing its AI-assisted legal invoice review, for instance, we first paired data scientists and domain experts to build the model. Then, we put the AI that they built to the test.

We gave one group of experts a set of invoices to review manually. We gave another group the same set of invoices but accompanied by AI scores provided by our newly built model. We did this repeatedly, so we could track the results over time.

The experts with AI were able to generate greater savings sometimes saving four times more than the control group. The AI acted as a highlighter, allowing them to focus on items that demanded greater due diligence. But humans were still part of the review process.

Once you understand that AI is not going to replace human talent, it becomes more obvious that you need the right people to get the most out of the technology.

In the beginning, we had more data scientists (as theyre commonly called) than we did domain experts. But domain experts are the ones who know which processes and customer experiences are best suited to be improved by AI.

Weve continued to grow our roster of domain experts, and they use AI more frequently than our data scientists.

Additionally, theyre the ones driving enhancements, as they have a better understanding of what problems need to be solved.

Not all companies can build their own AI models in-house, though. If youre looking to choose a partner, pick one with the most usage.

Ask potential partners how many customers are using their models and how many years of experience their models have. Many companies will throw out all the right buzzwords.

But a tried-and-true model is the key to getting the most out of artificial intelligence.

According to McKinsey, by the year 2025, data will be embedded in every decision, interaction, and process. But in the meantime, its important to prioritize use cases based on which problems are most suitable for AI.

To that end, ask yourself: What decision are we trying to improve? Are there a lot of transactions happening? Do we have sufficient data? Is there an opportunity to create a feedback loop?

Once again, the right mix of data scientists and domain experts is key to answering these questions.

In some cases, people use AI for quality assurance checks. Other times, its used for predictive insights. Regardless, its very important to analyze the why of your use case before you start building the model.

Our AI-assisted invoice review was an appealing use case because we had so much data on legal spend already. This gave us a huge head start when it came time to build our models.

The promise of artificial intelligence cannot be understated; it will be commonplace in corporate legal departments in no time. And yet, AI is not a plug-and-play solution thats going to make decisions for you.

Instead, it should enable your experts to make better decisions for themselves. AI isnt meant to replace human beings; its meant to augment their knowledge. Plan accordingly.

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How legal departments can get the most out of artificial intelligence - Wolters Kluwer

Artificial Intelligence Predicts Genetics of Cancerous Brain Tumors … – Neuroscience News

Summary: New artificial intelligence technology is able to screen for genetic mutations in brain cancer tumors in less than 90 seconds.

Source: University of Michigan

Using artificial intelligence, researchers have discovered how to screen for genetic mutations in cancerous brain tumors in under 90 seconds and possibly streamline the diagnosis and treatment of gliomas, a study suggests.

A team of neurosurgeons and engineers at Michigan Medicine, in collaboration with investigators from New York University, University of California, San Francisco and others, developed an AI-based diagnostic screening system called DeepGlioma that uses rapid imaging to analyze tumor specimens taken during an operation and detect genetic mutations more rapidly.

In a study of more than 150 patients with diffuse glioma, the most common and deadly primary brain tumor, the newly developed system identified mutations used by the World Health Organization to define molecular subgroups of the condition with an average accuracy over 90%.

The results arepublished inNature Medicine.

This AI-based tool has the potential to improve the access and speed of diagnosis and care of patients with deadly brain tumors, said lead author and creator of DeepGliomaTodd Hollon, M.D., a neurosurgeon at University of Michigan Health and assistant professor of neurosurgery at U-M Medical School.

Molecular classification is increasingly central to the diagnosis and treatment of gliomas, as the benefits and risks of surgery vary among brain tumor patients depending on their genetic makeup.

In fact, patients with a specific type of diffuse glioma called astrocytomas cangain an average of five yearswith complete tumor removal compared to other diffuse glioma subtypes.

However, access to molecular testing for diffuse glioma is limited and not uniformly available at centers that treat patients with brain tumors. When it is available, Hollon says, the turnaround time for results can take days, even weeks.

Barriers to molecular diagnosis can result in suboptimal care for patients with brain tumors, complicating surgical decision-making and selection of chemoradiation regimens, Hollon said.

Prior to DeepGlioma, surgeons did not have a method to differentiate diffuse gliomas during surgery. An idea that started in 2019, the system combines deep neural networks with an optical imaging method known as stimulated Raman histology, which was also developed at U-M, to image brain tumor tissue in real time.

DeepGlioma creates an avenue for accurate and more timely identification that would give providers a better chance to define treatments and predict patient prognosis, Hollon said.

Even with optimal standard-of-care treatment, patients with diffuse glioma face limited treatment options. The median survival time for patients with malignant diffuse gliomas is only 18 months.

While the development of medications to treat the tumors is essential,fewer than 10%of patients with glioma are enrolled in clinical trials, which often limit participation by molecular subgroups. Researchers hope that DeepGlioma can be a catalyst for early trial enrollment.

Progress in the treatment of the most deadly brain tumors has been limited in the past decades- in part because it has been hard to identify the patients who would benefit most from targeted therapies, said senior authorDaniel Orringer, M.D., an associate professor of neurosurgery and pathology at NYU Grossman School of Medicine, who developed stimulated Raman histology.

Rapid methods for molecular classification hold great promise for rethinking clinical trial design and bringing new therapies to patients.

Additional authors include Cheng Jiang, Asadur Chowdury, Akhil Kondepudi, Arjun Adapa, Wajd Al-Holou, Jason Heth, Oren Sagher, Maria Castro, Sandra Camelo-Piragua, Honglak Lee, all of University of Michigan, Mustafa Nasir-Moin, John Golfinos, Matija Snuderl, all of New York University, Alexander Aabedi, Pedro Lowenstein, Mitchel Berger, Shawn Hervey-Jumper, all of University of California, San Francisco, Lisa Irina Wadiura, Georg Widhalm, both of Medical University Vienna, Volker Neuschmelting, David Reinecke, Niklas von Spreckelsen, all of University Hospital Cologne, and Christian Freudiger, Invenio Imaging, Inc.

Funding: This work was supported by the National Institutes of Health, Cook Family Brain Tumor Research Fund, the Mark Trauner Brain Research Fund, the Zenkel Family Foundation, Ians Friends Foundation and the UM Precision Health Investigators Awards grant program.

Author: Noah FromsonSource: University of MichiganContact: Noah Fromson University of MichiganImage: The image is in the public domain

Original Research: Closed access.Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging by Todd Hollon et al. Nature Medicine

Abstract

Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging

Molecular classification has transformed the management of brain tumors by enabling more accurate prognostication and personalized treatment. However, timely molecular diagnostic testing for patients with brain tumors is limited, complicating surgical and adjuvant treatment and obstructing clinical trial enrollment.

In this study, we developed DeepGlioma, a rapid (<90seconds), artificial-intelligence-based diagnostic screening system to streamline the molecular diagnosis of diffuse gliomas.

DeepGlioma is trained using a multimodal dataset that includes stimulated Raman histology (SRH); a rapid, label-free, non-consumptive, optical imaging method; and large-scale, public genomic data. In a prospective, multicenter, international testing cohort of patients with diffuse glioma (n=153) who underwent real-time SRH imaging, we demonstrate that DeepGlioma can predict the molecular alterations used by the World Health Organization to define the adult-type diffuse glioma taxonomy (IDH mutation, 1p19q co-deletion and ATRX mutation), achieving a mean molecular classification accuracy of 93.31.6%.

Our results represent how artificial intelligence and optical histology can be used to provide a rapid and scalable adjunct to wet lab methods for the molecular screening of patients with diffuse glioma.

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Artificial Intelligence Predicts Genetics of Cancerous Brain Tumors ... - Neuroscience News