Archive for the ‘Artificial Intelligence’ Category

Maximize The Promise And Minimize The Perils Of Artificial Intelligence (AI) – Forbes

How businesses can use artificial intelligence (AI) to their advantage, perhaps even in a ... [+] transformative way, without turning the pursuit of AI advantage into a quixotic quest

Frankly, I was hoping an artificial intelligence (AI) algorithm would write this column for me, because who knows more about AI than the mysterious little gremlins that make machine learning possible? That, alas, didnt happen; so Im on my own.

Like most people in business, I dont need any convincing that artificial intelligence (for most companies in many areas of their operations) will become a game-changer.

Still, it remains a fluid, if not amorphous, concept in many respects. What, exactly, can we expect AI to do for us that were not already doingor how will it improve what were doing by doing it better, faster, cheaper, with greater insight or fewer errors?

As an important article (Winning With AI) in the MIT Sloan Management Review put it back in October, AI can be revolutionary, but executives must act strategically. [And] acting strategically means deciding what not to do. Thats not as easy as it sounds.

The problem I have with most discussions of artificial intelligence is that they assume the reader or listener already understands the promises and perils of AI. But based on my conversations with a lot of very intelligent people I dont think thats always the case.

As Amir Husain, founder and CEO of the Austin, Texas-based machine learning company, SparkCognition, explained to Business News Daily last spring, Artificial intelligence is kind of the second coming of software. Its a form of software that makes decisions on its own, thats able to act even in situations not foreseen by the programmers.

AI is so ubiquitous we hardly even think about it. As the Business News Daily article pointed out: Most of us interact with artificial intelligence in some form or another on a daily basis. From the mundane to the breathtaking, artificial intelligence is already disrupting virtually every business process in every industry.

Examples abound: online searches, spam filters, smart personal assistants, such as Alexa, Echo, Google Home and Siri, the programs that protect our information when we buy (or sell) something online, voice to text programs, smart-auto technologies, programs that automatically sound alarms or shut down operating systems when problems are identified, security alarm systems, even those annoying pop-up ads that follow us throughout the day. To one degree or another, theyre all based on or impacted by AI.

In other words, most of us are far more familiar with AIintimately sothan we give ourselves credit for.

The business question is (as the Sloan article correctly put it): How can executives exploit the opportunities, manage the risks, and minimize the difficulties associated with AI? Put another way, how can they use it to their advantage, perhaps even in a transformative way, without turning the pursuit of AI advantage into a quixotic questkeeping in mind that acting strategically involves deciding what not to do as well as pushing ahead and taking chances in some areas?

Some suggestions from the MIT Sloan Management Review article:

First: Dont treat AI initiatives as everyday technology gambits. Theyre more important than that. Run them from the C suite and closely coordinate them with other digital transformation efforts.

Second: Be sure to coordinate AI with the companys overall business strategy. One of the surest ways to come up shortas most AI initiatives do [from 40% to 70%, according to the Sloan article]is to focus AI narrowly on one set of priorities while the company is equally or more concerned with others. While AI can help companies reduce costs, for example, by identifying waste and inefficiencies, growing the business may be a higher priority.

The Hartford, Conn.-based insurance company, Aetna (now a subsidiary of CVS), for example, has been using AI to prevent fraud and uncover overpaymentstypical insurance company concerns. Its also been using AI to design products and increase customers and customer engagement. In one Medicare-related Aetna product, the article notes, designers used AI to customize benefits, leading to 180% growth in new member acquisition. More long term, Aetnas head of analytics, VP Ali Keshavarz, told the authors Aetnas goal is to use AI to become the first place customers go when they are thinking about their health.

Third: This may be obvious to the geeks among us, but perhaps less so to the more technology-challenged: Be sure to align the production of AI with the consumption of AI.

Fourth: Invest in AI talent, data and process change in addition to (and often more so than) AI technology. Recognize that every successful AI undertaking is the product of a great group of people. While some of this talent should be home grown, youll also have to hire from the outside: bring people in to develop and enhance your internal capabilities. Thats a fact of modern business life.

As with everything else in business, all companies are different. Their needs are different. Their available resources (financial, talent, patience) are different. And their goals and expectations should be different.

Its important to take the time to understand how to maximize the promise and minimize the pitfalls of AI. If you do, youre more likely to succeed.

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Maximize The Promise And Minimize The Perils Of Artificial Intelligence (AI) - Forbes

The Artificial Intelligence Industry and Global Challenges – Forbes

Whoever controls the strongest artificial intelligences controls the world.

Artificial intelligence is the most important technology of the 21st century. It is therefore important to understand global ambitions and movements.

In this article I examine the global artificial intelligence industry and in this context consider the aspects of politics, data, economy, start-ups, financing, research and infrastructure.

I will only briefly discuss the current superpowers China and the USA, as I will dedicate a separate article to each of them.

The question that we must ask ourselves in the end is how humanity will deal with the global challenges.

So far, the first wave of digitization has developed without much government influence. Although there are now plans to break Google's monopoly (USA and Europe), for example by imposing European fines on Google and Facebook, politics is lagging behind the market by over a decade.

As far as AI is concerned, for the first time in recent history I have observed a multitude of initiatives, strategies and actions by dozens of governments around the world - with very different goals and approaches.

Artificial intelligence is and remains an issue that politicians and administrations of all nations have to deal with.

AIs are relevant for climate protection and economic policy.

AIs influence the governance of domestic industry, the security and privacy of citizens.

A long-term strategy for the establishment and development of own AIs is crucial. But it is also expensive. Europe in particular has problems deciding in favour of long-term and investment-intensive strategies.

Fabian Westerheide

China has a clear vision of how country wants to master artificial intelligence. From China's point of view, artificial intelligence is an important tool for strong foreign policy, military dominance, economic success and for controlling one's own population.

The USA benefits from a strong research cluster and the super corporations Google, Microsoft, Facebook and Amazon, each of which is in the lead of the AI development.

Although the USA has not yet found a red line under President Trump, the state has been promoting the research and implementation of AIs for decades through its countless secret services and ministries.

Canada and Israel have become equally important but smaller players in the global competition for AI rule.

Israel, always very technologically strong, has more AI companies than Germany and France put together (see also our study Global Artificial Intelligence Landscape). In Israel, there is a close network of universities, access to the Asian and American capital markets, close cooperation with the military and the government. The Israeli company Mobileye was bought by Intel for $15 billion and is just one example of a thriving AI ecosystem.

Canada benefits greatly from the renaissance of deep learning in the last 7 years. Geoffrey Hinton, Yann LeCun and Yoshua Bengio are three of the strongest researchers in this technology. All three have researched at different times in the Canadian Institute for Advanced Research. Together they have survived the last "AI winter" and have been shaping the market ever since.

In addition, Canada has a clear AI strategy, research, investment and implementation have been promoted for years.

Also worth mentioning are Japan, Korea and India, which have good prerequisites for playing a relevant role in the AI industry in the coming years.

A reading reference at this point is the report of national strategies of artificial intelligence of the Konrad Adenauer Foundation (Part 1 and Part 2).

While politics provides the framework conditions for research, financing, education, data, promotion and regulation, in the medium term AIs must be developed by companies and brought onto the market.

First of all, national interests have to be taken into account.

These include, often with their own agenda and independently, global corporations with their own AI research and AI products.

In my view, Google (Alphabet), Amazon and Microsoft are global leaders. The Chinese Internet giants Alibaba, Baidu and Tencent are also relevant players.

There are two types of companies: Those that develop and sell AI as a core product and those that use AI to complement their value chain.

Either way, any company active today has to deal with artificial intelligence. On the one hand, AIs can replace existing business models, and on the other hand, they can be integrated into countless company-internal processes: Accounting, controlling, production, marketing, sales, administration, personnel management and recruiting.

By the way, this is the primary driver of applied artificial intelligence: reduce costs and maximize profits.

And, of course, it's also about control. Every AI used takes over activities that were previously performed by humans. Often, after a while of training, the AI is faster, more efficient and cheaper than the human being was before.

People become ill, they need holidays, food and sleep. They have to be entertained, quit or retire. AIs work 24/7 and do not demand a wage increase.

The more companies use AIs, the more independent they become of human labour.

The foundation of any artificial intelligence is data. We therefore need data on several points.

First of all, we need data for the research and training of narrow artificial intelligences. The more digital your business model is, the more data you have.

For this reason, marketing leaders (Google, Facebook), software companies (Salesforce, Microsoft) and e-commerce retailers (Zalando, Amazon) have been heavily involved in AI for years.

Some banks also recognized the trend early on. Therefore Goldman Sachs and J.P. Morgan have already recruited thousands of employees with a focus on machine learning and data science.

Those who have their own data can achieve an enormous competitive advantage.

Those who have no data have to collect, store and evaluate data.

However, this is where the different national data protection laws come in, which is why Europe is at a disadvantage.

GDPR/DSVGO may indeed have the good intention to create a European data internal market, but currently form an enormous location disadvantage for Europe.

The fear of the regulation paralyzes whole industries. Personal discussions with clinics and doctors showed me that the health industry no longer shares any data. This literally costs human lives, because this obstacle is detrimental to health research and life-prolonging algorithms.

This is just one example among many.

Uncertainty about data is paralysing our entire European industry. For fear of penalties, data is not collected at all. We are creating a culture of data anxiety at a time when data is actually our strength.

Europe is the most important data market in the world, but we are wasting our potential.

China, on the other hand, is the extreme opposite. The state helps with a lively exchange and centralization of data (more on this in the chapter on China). In addition, the population has fewer concerns about the free handling of data.

De facto, privacy no longer exists in the 21st century. Every digital action is measured and stored. However, we Europeans are sticking to an old ideal.

Start-ups are essential for any economy because they take on two essential functions of an ecosystem.

Start-ups are drivers of innovation. These young companies are often more courageous, faster and more flexible in developing new products than established companies. Backed by the capital of venture capital funds and business angels, start-ups take high risks in the expectation of extraordinary success.

Although 95% of start-ups do not survive the first 5 years, the entire ecosystem benefits from them.

Companies can buy new products and innovations through acquisitions.

Former employees find new jobs and transfer their knowledge.

Investors and founders learn and take their knowledge with them into new projects.

Perhaps the young company will survive the 5-year threshold. It secures financing (from seed to IPO), gains talent, grows, develops products for which customers pay, scales and becomes a corporation. Facebook, Google, Apple, Amazon, Uber - all started out as start-ups and are now dominant market leaders.

Charles-douard Boue, former CEO of Roland Berger, said at the 2018 Rise of AI conference that the next wave of trillion-dollar companies will mainly be AI companies.

This won't work without start-ups. That's why we need to encourage building start-ups.

The rediscovery of Deep Learning was only the beginning. The field has evolved through new approaches from CNN, GAN to evolutionary algorithms (Prof. Damian Borth's presentation at the 2017 Rise of AI conference is a good introduction to deep learning).

Computational linguistics around NLP and NLG has also made enormous leaps.

Today, hundreds of thousands of narrow artificial intelligence applications are based on the research results of the last 30 years, after we reached the critical volume of computing power and data availability in 2012.

Where do the research results come from?

On the one hand, they come from universities. MIT, Stanford, Carnegie Mellon University and Berkley are lighthouses in AI research (see also the AI index from Stanford).

MIT alone is investing 1 billion dollars in the training of new AI degree programmes by 2020.

On the other hand, companies have now become a major driver of AI research. You should know Google DeepMind. Microsoft has over 8,000 AI researchers.

Leading minds conduct research for corporations with more data and financial resources: Richard Socher (Salesforce), Yann LeCun (Facebook), Andrew Ng (until 2017 Baidu) or Demis Hassabis (Google).

European universities and corporations, on the other hand, are not leaders in the field of AI research. Of course, we also have smart minds like Prof. Jrgen Schmidhuber, Prof. Francesca Rossi and Prof. Hans Uszkoreit.

In addition, there are AI courses at KIT, TU Munich, TU Berlin, the University of Osnabrck (Cognitive Science), Oxford and Cambridge University.

But all this is just mediocrity and not internationally recognized top-level research.

Instead, the DFKI (German Research Institute for Artificial Intelligence), dozens of Max Planck Institutes and Fraunhofer Institutes in Germany in particular are primarily engaged in applied research. But even these institutes do not manage to play in the first league in the global competition for talent, data and capital.

But it is precisely research that will be decisive in the coming decades when it comes to the question of who will develop the first general artificial intelligences.

Video recommendation: Lecture by Prof. Hans Uszkoreit at the Rise-of-AI Conference 2017 on Super Intelligence.

By infrastructure I mean not only the availability of data but also the necessary computing and performance capacities.

NVIDIA used to be known for their graphics cards among gamers. Today, NVIDIA is one of the leading manufacturers of GPUs, which are increasingly used for AI applications. Google, Intel and many other companies are very active in the development of new AI chips in various forms.

At the same time, Microsoft, AWS, Google and IBM are expanding cloud capacity around the world to meet growing demand.

While China will focus strongly on 5G, which is critical for real-time AI applications and the networked industry, Europe will not play a leading role in this technology issue either.

The development of artificial intelligence is expensive.

Top AI researchers are rare and receive salaries of up to 300,000 per year.

Data must be collected, sorted and labelled. Developing AI models takes time for experiments, mistakes and new methods.

AIs need data, must be trained and educated.

These costs are borne by companies, start-ups, investors and also the state.

China has understood this and is investing over 130 billion euros in the Chinese AI market. Provinces such as Beijing, Shanghai and Tianjing are each investing tens of billions in local AI industry.

In the USA, Google, IBM, Microsoft, Amazon, Facebook and Apple have already invested over 55 billion dollars internally by 2015.

Without money, there is no artificial intelligence.

And once again Europe is too stingy to invest in the future.

A comparison of the orders of magnitude: In 2018, the German Bundestag had budgeted as much as 500,000 for AI funding. A further 500 million is planned, but the funds are not yet available.

Progress will not succeed in this way.

At the same time, China is financing 400 new chairs for AI. To date, we have seen nothing of the 100 new professorships planned under the German AI Strategy.

In this context, I would like to praise Great Britain because it is going against the trend in Europe - despite Brexit. More money is being made available on the island for start-ups and universities in the field of artificial intelligence.

If you want to know more about the current state of AI, I recommend the State-of-AI-Report 2019 and my presentation of the Rise of AI 2019 as video.

As I mentioned earlier, Europe is currently losing the competition for the leading AI nations.

While Europe is still considering whether to compete at all, China, the US, Israel, the UK and Canada are already competing for data, markets and talent.

Our problems in Europe are homemade, they are the result of our inertia, lack of vision and ambitions.

There is a lack of money for education. Not only are our schools and universities underfunded, but so is the education labour market. Our children are not learning enough about digital skills. Our students rarely take AI-relevant subjects. Our working population lacks retraining opportunities that also meet the needs of the growing digital industry.

The transfer of research results to industry is sluggish. Results either disappear into the drawer, or the IP transfer is in bureaucratic terms a horror, especially for young companies and spin-offs.

Our European AI start-ups are significantly underfinanced. Those who currently need money from investors must market e-bikes and e-scooters, but they should not include technology. The more complex the product, the more difficult it is to get capital. The simpler the business model, the faster the accounts are filled.

Although many talents from Asia and America want to work in Europe, it has become bureaucratically complicated. Since the wave of refugees, the offices have been overwhelmed. It is almost impossible to hire talented AI developers from Iran, Russia or China. There is currently a spirit of rejection rather than openness in Europe.

Europe lacks a single strategy. Countries such as Finland, Sweden, the Netherlands or France have their own AI strategies and, moreover, a great deal of ambition. Germany, in particular, is blocking a common European approach and thus possible success.

When I was with the European Commission in 2018, a Bulgarian researcher said that she would be happy if her country had a plan at all. According to her, entire sections of Europe are significantly worse off than we are in Western Europe.

I am not saying that politics must solve all our problems. Companies still have to build products, founders have to start start-ups, VCs have to finance these start-ups and researchers have to do research.

But politicians can support us with a clear strategy. It can build up regulatory structures instead of inhibiting them. It can create incentives for investment and act as a role model. And it must be a matter of course for politicians to take care of the education of pupils, students and qualified further education in general.

On paper you can read all this (AI strategy of the German Federal Government), but in practice nothing happens.

Europe is marked by power struggles, egoism and technology phobia.

But Europe is only part of the world and must adapt to a global power order.

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The Artificial Intelligence Industry and Global Challenges - Forbes

Need a New Topic for Thanksgiving Dinner? How to Explain Artificial Intelligence (AI) to Anyone…and Make it Fun! – Forbes

Thanksgiving dinners are known to be the stage of controversial discussions: religion and politics are amongst the conversation topics that make these family gatherings awkward for some...and dreadful for many.

So, for this decades last Thanksgiving, how about switching it up and talking about Artificial Intelligence (AI)?! After all, every company seems to be doing AI. You can do your part to help explain it.

Here are some simple, many even silly, steps to get your Thanksgiving meal back on track with AI.

What the heck is AI anyways?!

If its a 5-year-old or a 75-year-old that asks today: What is AI?, use the following three steps:

1) The academic explanation

You could say: "Artificial Intelligence refers to the science that helps computers do things that only humans typically can do. For instance: making a decision as the result of something we learned over time, or, altering our opinion based on new information, deducting the answer to a complex situation based on incomplete data.

If this intro works, then you can further theorize how humans have special powers like imagination, judgment or deduction.

OR, you can move to step #2.

2) Pull up a calculator

Many of my fellow technologists will probably cringe at the idea that one could reduce the concept of AI to a calculator. But they are suffering from the Curse of Knowledge: they know more than most people do and they forget what it feels to not know.

To understand AI and the service it provides humans, youve got to start with the most basic concept attached to AI: the algorithmic sequence. AI is the result of algorithms and their sequence. If your audience doesnt understand that, you wont get very far.

Now, ask your audience to grab a pen and a paper. Give your human subject a series of complex calculations. Time them. Then, enter the same sequence into the calculator while you ask the human to time you as you're getting the answer. If all goes well, the human will witness that the machine was much faster. They should also understand that a) the machine stores more information than their brain ever could, and that b) it can retrieve the right answer 100% of the time, and faster than they could ever hope. You can probably also explain that the machine never will fail as a result of stress or confusion or emotions that only humans have.

Now youre ready for step #3.

3) The "Calculator 2.0 Moment": Play Twenty Questions

Twenty questions is a simple game that requires deductive reasoning and creativity. One player secretly thinks of a thing (typically an animal, vegetable, or mineral). The other players try to guess their secret by asking 20 questions.

Spend 5 or 10 mins playing Twenty Questions with your little nephew or grandma. Spend enough time playing the game so they can understand what deductive reasoning and creativity feel like and curse of knowledge.

Now, pull up an Amazon Alexa (or similar smart device). Play Twenty Questions with it. This should result in what I call the Calculator 2.0 Moment. Its that moment when humans realize that machines can do things they can.

Its that moment when they realize that a big part of "our lives run on math.

And when things run on math, they can be decoded, recoded and improved to provide better results, faster.

Thats what Artificial Intelligence is all about.

Happy Thanksgiving to all!

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Need a New Topic for Thanksgiving Dinner? How to Explain Artificial Intelligence (AI) to Anyone...and Make it Fun! - Forbes

The impact of artificial intelligence on humans – Bangkok Post

Will the machines take control? Not if we focus on developing the skills that AI cannot replicate

From Siri, the virtual assistant in Apple mobile devices, to self-driving cars, artificial intelligence (AI) is progressing rapidly, outperforming humans at some tasks. As with the majority of the changes happening globally, there will be positive and negative impacts as AI continues to shape the world we live in. Every single one of us will have to reckon with our ability to balance the human way of life and the transition to the AI cosmos.

According to a report by the technology research group IDC, spending on AI is expected to reach US$46 billion by 2020 with no signs of slowing down. AI is definitely on the rise in both business and life in general. The question is, will humans eventually lose control as machines become super-intelligent? Unforeseen consequences are likely whenever a new technology is introduced, and AI is no exception.

It is obvious that AI is a disruptive technology, revolutionising businesses and bringing new approaches to decision-making based on measurable outcomes. It can enhance efficiency and production volume, while cultivating new opportunities for revenue to flourish.

We have to face the fact that humans arent always the best at tedious and repetitive tasks, whereas machines dont get tired or complain. This is where AI is starting to play an important role: freeing humans from drudgery so that we can focus on interpersonal relations and more creative work.

Is it true that robots and AI will destroy jobs? That is something we hear quite often. Everyone has their own opinions about the pluses and minuses of the technology. However, if you think about it in a positive way, AI is actually encouraging evolution in the job market, as candidates come to realise they need to develop new types of skills in order to secure fulfilling work amid rapid technological advancements.

The truth is, people will still work, but they will work better with the assistance of AI. In other words, the unparalleled duo of human and machines coming together will soon turn into the new normal in the workforce. Already there are many routine white-collar tasks such as answering emails, data entry and related responsibilities that can be handled by intelligent assistants if businesses are prepared to recognise the potential.

Away from the office, we can see that more and more people are living in smart homes or equipping their residences with hardware and software that can reduce energy usage and provide better security, among other benefits. AI is also having a profound impact on healthcare, leading to improved diagnosis and treatment of many conditions, leading to healthier citizens and healthier economies.

The ability of technology to answer more questions, solve more problems and innovate in previously unimaginable ways goes beyond the capacity of the human brain for better or worse, depending on how one perceives this subject. The elevation of technology will allow individuals to focus on higher functions, with improved quality living standards.

Challenges will continue to come and go, but the biggest one will be for humans to find their place in this new world, by staking a claim to all the activities that call for their unique human abilities.

A study by PwC forecast that 7 million existing jobs will be replaced by AI in the UK from 2017 to 2037. However, 7.2 million new jobs could be created as well. Yes, many humans are wondering whether they will be part of the 7 million or part of the 7.2 million. Living with this uncertainty is a struggle for many given the transformative impact of AI on our society and the economic, political, legal and regulatory implications that need to be prepared for.

At its core, AI is about imitating human thought processes. Human beings essentially have to teach AI the how-to of practically everything, but AI cannot be taught how to be empathic, something only humans can do. It is one thing to allow machines to predict and help solve problems; it is another to purposely make them control the ways in which people will be made redundant.

Therefore, it is vital for us to be more sceptical of AI and recognise its shortcomings together with its potential. By focusing more on training people in soft skills, starting in school, we can help produce a greater number of employable humans who will be able to work alongside machines to deliver the best of both worlds.

Arinya Talerngsri is Chief Capability Officer and Managing Director at SEAC - Southeast Asias Lifelong Learning Center. She can be reached by email at arinya_t@seasiacenter.com or https://www.linkedin.com/in/arinya-talerngsri-53b81aa. Explore and experience our lifelong learning ecosystem today at https://www.yournextu.com

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The impact of artificial intelligence on humans - Bangkok Post

Dyno Therapeutics Announces Research Published in Science Enabling Artificial Intelligence Approach to Create New AAV Capsids for Gene Therapies -…

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Dyno Therapeutics, a biotechnology company pioneering use of artificial intelligence in gene therapy, today announced a publication in the journal Science that demonstrates the power of a comprehensive machine-guided approach to engineer improved capsids for gene therapy delivery. The research was conducted by Dyno co-founders Eric D. Kelsic, Ph.D. and Sam Sinai, Ph.D., together with colleague Pierce Ogden, Ph.D., at Harvards Wyss Institute for Biologically Inspired Engineering and the Harvard Medical School laboratory of George M. Church, Ph.D., a Dyno scientific co-founder. The publication, entitled Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design, is available here.1

AAV capsids are presently the most commonly used vector for gene therapy because of their established ability to deliver genetic material to patient organs with a proven safety profile. However, there are only a few naturally occurring AAV capsids, and they are deficient in essential properties for optimal gene therapy, such as targeted delivery, evasion of the immune system, higher levels of viral production, and greater transduction efficiency. Starting at Harvard in 2015, the authors set out to overcome the limitations of current capsids by developing new machine-guided technologies to rapidly and systematically engineer a suite of new, improved capsids for widespread therapeutic use.

In the research published in Science, the authors demonstrate the advance of their unique machine-guided approach to AAV engineering. Previous approaches have been limited by the difficulty of altering a complex capsid protein without breaking its function and by the general lack of knowledge regarding how AAV capsids interact with the body. Historically, rather than addressing this challenge directly, the most popular approaches to capsid engineering have taken a roundabout solution: generating libraries of new capsids by making random changes to the protein. However, since most random changes to the capsid actually result in decreased function, such random libraries contain few viable capsids, much less improved ones. Recognizing the limitation of conventionally generated capsid libraries, the authors implemented a machine-guided approach that gathered a vast amount of data using new high-throughput measurement technologies to teach them how to build better libraries and, ultimately, lead to synthetic capsids with optimized delivery properties.

Focusing on the AAV2 capsid, the authors generated a complete landscape of all single codon substitutions, insertions and deletions, then measured the functional properties important for in vivo delivery. They then used a machine-guided approach, leveraging these data to efficiently generate diverse libraries of AAV capsids with multiple changes that targeted the mouse liver and that outperformed AAVs generated by conventional random mutagenesis approaches. In the process, the authors systematic efforts unexpectedly revealed the existence of a previously-unrecognized protein encoded within the sequence of all the most popular AAV capsids, which they termed membrane-associated accessory protein (MAAP). The authors believe that the protein plays a role in the natural life cycle of AAV.

This is just the beginning of machine-guided engineering of AAV capsids to transform gene therapy, underscores co-author Sam Sinai, Ph.D., Lead Machine Learning Scientist and co-founder of Dyno Therapeutics. The success of the simple linear models used in this study has led us to pursue more data and higher capacity machine learning models, where the potential for improvement in capsid designs feels boundless.

The results in the Science publication demonstrate, for the first time, the power of linking a comprehensive set of advanced techniques large scale DNA synthesis, pooled in vitro and in vivo screens, next-generation sequencing readouts, and iterative machine-guided capsid design to generate optimized synthetic AAV capsids, explains co-first and co-corresponding author Eric D. Kelsic, Ph.D., CEO and co-founder of Dyno Therapeutics. At Dyno, our team is committed to advancing these technologies to identify capsids that meet the urgent needs of patients who can benefit from gene therapies.

About Dyno TherapeuticsDyno Therapeutics is a pioneer in applying artificial intelligence to gene therapy. The companys powerful and proprietary genetic engineering platform is designed to rapidly and systematically develop improved AAV capsids that redefine the gene therapy landscape. Dyno was founded by experienced biotech entrepreneurs and leading scientists in the fields of synthetic biology, gene therapy, and machine learning. The company is located in Cambridge, Massachusetts. For additional information, please visit the company website at http://www.dynotx.com

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Dyno Therapeutics Announces Research Published in Science Enabling Artificial Intelligence Approach to Create New AAV Capsids for Gene Therapies -...