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Newswise BOSTON Websites that market personalized cancer care services often overemphasize their purported benefits and downplay their limitations, and many sites offer genetic tests whose value for guiding cancer treatment has not been shown to be clinically useful, according to a new study from Dana-Farber Cancer Institute.
Internet marketing of cancer-related gene tests is unregulated. Therefore, there is wide variation in how these services are presented posing a challenge for consumers and their physicians, the researchers reported in the March 5, 2015 issue of the Journal of the National Cancer Institute.
We wanted to see if consumers are getting a balanced picture of benefits and limitations of these services, said Stacy Gray, MD, AM, first author of the report analyzing 55 websites marketing the services. We found a lot of variation. Some of the information is good, but all of it needs to be looked at critically by consumers and health care providers.
The study found that in general, the benefits of these personalized cancer products are reported much more frequently than are the limitations, said Gray. In addition, 88 percent of the websites offered one or more nonstandard tests that lacked evidence of clear clinical utility in routine oncology practice.
Gray is a medical oncologist and investigator at the Dana-Farber Center for Outcome and Policy Research. The senior author is Katherine Janeway, MD, a pediatric oncologist at Dana-Farber/Boston Childrens Cancer and Blood Disorders Center. In their report, the researchers noted that Internet marketing may be detrimental if it endorses products of unproven benefit.
The investigators analyzed personalized or precision cancer medicine (PCM) products and services marketed by private companies, academic medical centers, physicians, research institutes and other organizations.
PCM was defined by the authors as products or services that could be used to tailor, personalize, or individualize care based on genomic or tumor-derived data. PCM often refers to testing DNA from samples of a patients tumor to detect mutations or other genetic abnormalities that may help physicians predict how the disease will behave, and in a limited but growing number of cases select a drug or drugs targeted to the particular mutations found in the cancer. Such targeted agents may be more effective and cause fewer adverse side effects than standard chemotherapy.
These tests are termed somatic because they look at the genetic characteristic of the tumor itself. Another type of PCM testing, called germline, analyzes the patients personal genome a panel or set of inherited genes and other DNA and may turn up altered genes in a healthy person that raise his or her risk of developing cancer.
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Unregulated Web Marketing of Genetic Tests for Personalized Cancer Care Raises Concerns in New Study
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