Archive for the ‘Media Control’ Category

Over 2 million teens have tried vaping leading to more lung-related diseases, according to CDC – Houston Public Media

AP Photo/Craig Mitchelldyer, File

A new study from the Center for Disease Control and Prevention shows that more than 2.5 million middle and high schoolers have used an e-cigarette in the past month.

In the study released Thursday, the CDC reports that of the 2.5 million students, nearly half of the students surveyed used e-cigarettes on 20 or more of the past 30 days.

Dr. Pushan Jani, an associate professor at the McGovern Medical School at UTHealth, said hospital admissions in Houston reflect these numbers, and that it is believed 1 in 5 kids in Houston have tried vaping.

"We are taking care of more and more patients with EVALI," Jani said.

EVALI, or E-Cigarette or Vaping use-Associated Lung Injury, is defined by the American Lung Association as a newly named disease after the increase in severe lung illness cases related to e-cigarette and vaping products.

Jani said that over the past few years, many newer e-cigarette brands are cheaper and can be used for longer periods of time.

"They are available online without any legal repercussions from any government agencies," he said. "Even though there are laws in place for in-person sales."

Jani added that many websites that sell e-cigarettes do so without requiring any age documentation. He said parents should talk to their kids to make sure they understand the risks of e-cigarettes.

However, Jani also warned that confrontation may not always be the answer. He said some kids may need therapies to help them quit these products.

"Sometimes they may need Quit Therapies that we use for cigarettes," he said. "Nicotine can be very addictive. Kids can get hooked onto this within 2 or 3 days of using it."

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Over 2 million teens have tried vaping leading to more lung-related diseases, according to CDC - Houston Public Media

How Pat McAfee went from Colts punter to media superstardom: He has the gift – The Athletic

How did Pat McAfee start the transition from relatively unknown Colts punter to a media mogul who now is part of ESPNs College GameDay crew, hosts a wildly popular show on YouTube and both performed and worked as a commentator for World Wrestling Entertainment?

With a drunken, late-night swim in the not-so-pristine waters of the Broad Ripple Canal in Indianapolis almost exactly 12 years ago.

It had been a really long night in an endless stretch of really long nights for the then-23-year-old. While celebrating life at Old Pros Table, he bought a hundred shots of tequila for the patrons in the bar.

At some point, McAfee thought it would be a tremendous idea to walk outside and jump into the nearby canal. After doing the backstroke, or maybe it was the breaststroke, McAfee emerged. A passing motorist later saw the wet, shirtless McAfee strolling about and called the police.

Soon, his blotchy face and wild hair were splattered all over the TV, both locally and nationally. As mugshots go, it was a classic. But Tim McAfee, Pats father, was not at all amused. When Pat called him from jail, Tim acknowledged he had seen the news and hung up on his son.

Pat was mortified. The Colts, led by general manager Bill Polian, were incensed, and while some of us dismissed it as a silly stunt by a kid whose night spiraled out of control, his reputation took something of a beating in his adopted hometown.

Shortly thereafter, he started getting calls from Bob Kevoian, the now-retired host of the Bob & Tom Show, a fabulously successful national morning radio show that emanated from Indianapolis.

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How Pat McAfee went from Colts punter to media superstardom: He has the gift - The Athletic

Police worker accused of sharing photo of dead teenager on WhatsApp – The Guardian

Police have been hit by a new WhatsApp controversy, with a control room worker accused of sharing a picture from the scene where a teenager died after being struck by a train.

The accused worker was employed by British Transport Police (BTP) at the time.

The photograph was taken by police investigating the death of Lewis Williams, 18, after he was hit by a train in Slough in June 2022. It is claimed it was later shared via social media.

Williams father, Paul, told the Guardian that news of a gruesome picture of his sons death being shared had left him sickened and had exacerbated his grief.

He said his son was smart, had great potential and a really big heart. Williams wanted to be in the Royal Air Force, had previously done a reading before the royal family and was keen on history.

BTP said the image of Williams had been shared from the forces control room.

A former BTP employee, Joshua Tilt, 31, appeared on Friday at Birmingham magistrates court, charged with misconduct in public office.

The court heard he was accused of taking a photo on his personal mobile phone of a deceased member of the public and distributing it to others, between 20 June and 1 July this year.

The district judge David Wain granted Tilt bail until 4 November, when he will appear at Birmingham crown court.Paul Williams told the Guardian his son died under a train in Slough on 21 June.

Days later police came to visit the family: We were as a family trying to come to terms with the death of our son, and initially we had some comfort that he was at peace, but on 2 July all of that changed when the chief superintendent of British Transport Police told us a photo of his dismembered body [was] shared in a WhatsApp chat group.

I immediately felt sick. This was the first time that we were given the horrific detail about the state of Lewiss body. It is incomprehensible to us that someone would share such a picture, or how they were able to. When I think of Lewis now, all I can think of is that gruesome photo that has been shared, and we will have to live with this image for the rest of our lives.

In a statement, BTP, which operates on Britains transport network, said Tilt was charged with misconduct in a public office, following an investigation by BTPs professional standards department. The charges are in connection to an incident involving the sharing of an image from the forces control room. As is routine, the force referred itself to the IOPC [Independent Office for Police Conduct] who deemed the matter suitable for local investigation.

Williams said that in March 2022 his son was diagnosed with an emotionally unstable personality disorder: Lewis was popular, funny and kind. He had a really big heart and would always put other peoples problems ahead of his own. He touched so many peoples lives.

He was also incredibly smart, and his knowledge of history and the world was second to none. His teachers would always say how much potential he had. He would spend hours reading and researching any topic.

He was chosen to do a reading at the RAF 100 at Windsor Cathedral in front of members of the royal family. Lewis had dreams of joining the RAF one day.

Williams said his son had joined the air cadets when he was 12 and had risen to the rank of flight sergeant: He was very empathetic and great at reading other peoples feelings. His school friends, college friends and those from the squadron did tributes for him after his death. At the squadron they have his hoodie with the squadron number and a plaque placed on the wall in his memory.

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Police worker accused of sharing photo of dead teenager on WhatsApp - The Guardian

Why healthcare’s medical device challenges will never be addressed in isolation – SC Media

The governments push for threat sharing and collaboration, with the uptick in alerts directed to the healthcare sector, are a welcomed shift in the longstanding efforts to curtail cybersecurity challenges with overall awareness and cyber posture in the industry.

But awareness doesnt always translate into a viable solution, particularly when it comes to tackling the minutiae of medical devices. Due to the sheer complexity of the device ecosystem, resource constraints, and knowledge gaps, even the largest health systems struggle to solve the risk management challenges.

I think medical devices and biomed in general are really kind of the redheaded-stepchild of healthcare organizations because they're complex, and nobody really knows how to deal with them, said Ben Denkers, CynergisTeks chief innovation officer.

Consider the FBI alert on legacy medical devices, which resounded the bullhorn on risks associated with leveraging legacy tech in devices directly tied to patients. For many in healthcare, the messages rang familiar: groups like CHIME have long-warned of patch management issues and the impossibility of a real-time inventory in the healthcare environment. Similarly, the recommendations were rather vanilla: basic blocking and tackling at the end of the day.

Certainly, such reminders do no harm encouraging some healthcare entities to leverage technology as a safeguard to defend against a specific threat or to reduce overall risk. But some argue that the challenges facing many providers cant be boiled down into a singular problem or solution, and that the current assessment of risk could leave a vulnerable market unable to see the forest through the trees.

SC Media spoke to Denkers about this quandary, and how the market can better address multiple and sometimes conflicting hurdles to cybersecurity.

When the onslaught of ransomware attacks against healthcare began in 2016, the rallying cry was that there was no silver bullet to solve cybersecurity challenges. The sentiment remains, for both overall infrastructure and device security vulnerabilities.

As its likely always been in healthcare, the crux of its issues is actually a combination of resource and knowledge constraints, which are needed to truly have an effective security and privacy program, Denkers explained. Providers need a combination of people, processes, and technology to have a successful privacy and security program, even before its applied to a specific area like medical devices.

If you don't have enough resources, it's going to be problematic. If you don't have the right technology, you're going to have issues. And if you don't have the right processes to make sure all of those are working and effective, it doesn't do you any good, said Denkers.

That's the problem. It's not a singular issue of, hey, we don't have the right technology to stop the attack, he continued. Let's say, magically, you can wave your wand and put in some sort of endpoint protection on all the medical devices. Great. But what happens if you don't have the people to monitor the alerts or have to deal with a device being compromised? It doesn't really do you any good.

That means that even when a problem is identified, it still cant be remediated without the effective processes or controls. And if the problem persists, it can create downstream effects when the device remains in use, which could still cause patient safety impacts.

Further, if hospital leadership doesnt know how to use the actual security technology, its not going to do a whole lot, said Denkers. Others are struggling without the resources to manage or monitor the tools, or even tweak them to make it effective in the environment.

I've had countless conversations with individuals at healthcare organizations, and similarly where they've invested a lot of money in technology for it to sit in the corner because they don't have the resources or the know-how, or the physical resources to take the device and implement it, he added.

And they certainly don't have the resources to validate that it's working. Medical device security is important, it absolutely is. But you're also talking to organizations that probably, I would venture to guess, don't even have endpoint protection.

Some resource issues are financially driven; organizations dont have the money to make investments in the technology stack, or afford to hire the right people. Hiring challenges also persist for rural providers, who may not be able to physically get people into the organization.

Many rural hospitals face staffing challenges based on location alone, he said. Healthcare is facing all of these problems, not just with medical devices and the higher level of risk due to the direct attachment to care. But if you really start to unpeel the layers, you'll start to see that healthcare in general still isn't isn't necessarily the poster child for security and privacy programs.

Denkers posed an important question: if a car manufacturer had vehicles on the road that generally did what they were supposed to do, but passengers were at risk due to a faulty airbag, or malfunctioning brakes, what would happen? The manufacturer would be forced to make changes.

The reason why we're having to deal with these problems is because [medical devices] weren't properly developed from the beginning, he mused. It all starts with the software development life cycle, and where does SDLC start? It's whoever is developing the product or the solution.

If issues aren't properly vetted at the beginning of the development cycle, risks emerge. As Denkers sees it, it's the responsibility of the vendor to have a better product.

It's a snowball effect: you're never really actually going to catch up because it's just going to continue to get worse and worse and worse every time you have outdated software or end-of-life hardware and products.

It's interesting, those types of risks wouldn't be accepted in any other organization. But for some reason, we're dealing with people, which arguably have the highest rates of consequences, and it's okay, said Denkers.

The FBI alert was likely intended to reflect the current threats facing vulnerable platforms, warning that bad actors are increasingly using unpatched medical devices to gain a foothold on the network.

But the alert should instead serve as a guidepost: An exploit could ultimately impact the integrity and confidentiality of data, or even worse, cause disruptions in operational functions and impact patient safety.

Use this as a compass or a North Star, Denkers recommended, and review the guidance to verify just how well medical devices are being protected. Many in healthcare are in situations where they think they have certain safeguards in place, or some version of recommended safeguards, inadvertently miss the most important element amid the noise.

As Denkers plainly puts it, The question then really becomes: How effective is that control?

An entity may have endpoint protection or access controls, but be unaware of potential gaps in the environment, or unclear whether tools adequately address vulnerabilities. Some organizations generally don't have a mechanism in place to validate how effective controls are whether it be people, processes, or technology, he explained.

Segmentation is one of those areas where an entity might decide to separate certain devices from the main network, but then management of those devices is handled by another department. They set security and forget it. But as noted by Denkers, if they're connected to the network, they're still connected to patients.

And such oversights bring grave consequences. If a device or supporting infrastructure were to be compromised, and the device needs the internet to function or access certain portions of the environment, the medical devices cant function for patient care.

Depending on the organization's requirements, there can be many downstream effects from general compromises on the IT environment that become problematic quickly.

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Why healthcare's medical device challenges will never be addressed in isolation - SC Media

3D map reveals DNA organization within human retina cells – nih.gov

News Release

Friday, October 7, 2022

NIH scientists shed light on how genetic architecture determines gene expression, tissue-specific function, and disease phenotype in blinding diseases.

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cells nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. The study published in Nature Communications.

This is the first detailed integration of retinal regulatory genome topology with genetic variants associated with age-related macular degeneration (AMD) and glaucoma, two leading causes of vision loss and blindness, said the studys lead investigator, Anand Swaroop, Ph.D., senior investigator and chief of the Neurobiology Neurodegeneration and Repair Laboratory at the NEI, part of the National Institutes of Health.

Adult human retinal cells are highly specialized sensory neurons that do not divide, and are therefore relatively stable for exploring how the chromatins three-dimensional structure contributes to the expression of genetic information.

Chromatin fibers package long strands of DNA, which are spooled around histone proteins and then repeatedly looped to form highly compact structures. All those loops create multiple contact points where genetic sequences that code for proteins interact with gene regulatory sequences, such as super enhancers, promoters, and transcription factors.

Such non-coding sequences were long considered junk DNA. But more advanced studies demonstrate ways these sequences control which genes get transcribed and when, shedding light on the specific mechanisms by which non-coding regulatory elements exert control even when their location on a DNA strand is remote from the genes they regulate.

Using deep Hi-C sequencing, a tool used for studying 3D genome organization, the researchers created a high-resolution map that included 704 million contact points within retinal cell chromatin. Maps were constructed using post-mortem retinal samples from four human donors.

The researchers then integrated that chromatin topology map with datasets on retinal genes and regulatory elements. What emerged was a dynamic picture of interactions within chromatin over time, including gene activity hot spots and areas with varying degrees of insulation from other regions of DNA.

They found distinct patterns of interaction at retinal genes suggesting how chromatins 3D organization plays an important role in tissue-specific gene regulation.

Having such a high-resolution picture of genomic architecture will continue to provide insights into the genetic control of tissue-specific functions, Swaroop said.

Furthermore, similarities between mice and human chromatin organization suggest conservation across species, underscoring the relevance of chromatin organizational patterns for retinal gene regulation. More than a third (35.7%) of gene pairs interacting through a chromatin loop in mice also did so in human retina.

The researchers integrated the chromatin topology map with data on genetic variants identified from genome-wide association studies for their involvement in AMD and glaucoma, two leading causes of vision loss and blindness. The findings point to specific candidate causal genes involved in those diseases.

The integrated genome regulatory map will also assist in evaluating genes associated with other common retina-associated diseases such as diabetic retinopathy, determining missing heritability and understanding genotype-phenotype correlations in inherited retinal and macular diseases.

The study was supported by the NEI Intramural Research Program, grants ZIAEY000450 and ZIAEY000546.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research. To learn more about basic research, visit https://www.nih.gov/news-events/basic-research-digital-media-kit.

NEI leads the federal governments efforts to eliminate vision loss and improve quality of life through vision researchdriving innovation, fostering collaboration, expanding the vision workforce, and educating the public and key stakeholders. NEI supports basic and clinical science programs to develop sight-saving treatments and to broaden opportunities for people with vision impairment. For more information, visit https://www.nei.nih.gov.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

Marchal C, Singh N, Batz Z, Advani J, Jaeger C, Corso-Diaz X, and Swaroop A. High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci. Published October 7, 2022, Nature Communications. DOI:10.1038/s41467-022-33427-1.

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3D map reveals DNA organization within human retina cells - nih.gov