Mediaboss Marketing

Theeranan Tangthong,1,2 Thananchai Piroonpan,2 Velaphi C Thipe,3,4 Menka Khoobchandani,4,5 Kavita Katti,4,5 Kattesh V Katti,4 6 Wanvimol Pasanphan1,2

1Department of Materials Science, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, 10900, Thailand; 2Center of Radiation Processing for Polymer Modification and Nanotechnology (CRPN), Faculty of Science, Kasetsart University, Chatuchak, Bangkok, 10900, Thailand; 3Laboratrio de Ecotoxicologia - Centro de Qumica e Meio Ambiente - Instituto de Pesquisas Energticase Nucleares (IPEN) - Comisso Nacional de Energia Nuclear- IPEN/CNEN-SP, So Paulo, Brasil; 4Institute of Green Nanotechnology, University of Missouri, Columbia, MO, 65211, USA; 5Department of Radiology, University of Missouri, Columbia, MO, 65211, USA; 6Department of Physics, University of Missouri, Columbia, MO, 65211, USA

Correspondence: Wanvimol PasanphanDepartment of Materials Science, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Lat Yao, Chatuchak, Bangkok, 10900, ThailandTel +66 2562 5555 (Ext. 646518)Email wanvimol.p@ku.ac.thKattesh V KattiInstitute of Green Nanotechnology, University of Missouri, Columbia, MO, 65211, USATel +1 573 882-5656Fax +1 573 884-5679Email KattiK@health.missouri.edu

Introduction: Functionalization of water-soluble chitosan (WSCS) nanocolloids with, gold nanoparticles (AuNPs), and LyslLys3 (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-bombesin 1 14 (DOTA-BBN) peptide affords an innovative pathway to produce prostate tumor cell-specific nanomedicine agents with potential applications in molecular imaging and therapy.Methods: The preparation involves the production and full characterization of water-soluble chitosan (WSCS), via gamma () rays (80 kGy) irradiation, followed by DOTA-BBN conjugation for subsequent use as an effective template toward the synthesis of tumor cell-specific AuNPs-WSCS-DOTA-BBN.Results: The WSCS-DOTA-BBN polymeric nanoparticles (86 2.03 nm) served multiple roles as reducing and stabilizing agents in the overall template synthesis of tumor cell-targeted AuNPs. The AuNPs capped with WSCS and WSCS-DOTA-BBN exhibited average Au-core diameter of 17 8 nm and 20 7 nm with hydrodynamic diameters of 56 1 and 67 2 nm, respectively. The AuNPs-WSCS-DOTA-BBN showed optimum in vitro stability in biologically relevant solutions. The targeted AuNPs showed selective affinity toward GRP receptors overexpressed in prostate cancer cells (PC-3 and LNCaP).Discussion: The AuNPs-WSCS-DOTA-BBN displayed cytotoxicity effects against PC-3 and LNCaP cancer cells, with concomitant safety toward the HAECs normal cells. The AuNPs-WSCS-DOTA-BBN showed synergistic targeting toward tumor cells with selective cytotoxicity of AuNPs towards PC-3 and LNCaP cells. Our investigations provide compelling evidence that AuNPs functionalized with WSCS-DOTA-BBN is an innovative nanomedicine approach for use in molecular imaging and therapy of GRP receptor-positive tumors. The template synthesis of AuNPs-WSCS-DOTA-BBN serves as an excellent non-radioactive surrogate for the development of the corresponding 198AuNPs theragnostic nanoradiopharmaceutical for use in cancer diagnosis and therapy.

Keywords: DOTA-bombesin, gold nanoparticle, water-soluble chitosan, nanoradiopharmaceutical, prostate cancer

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Targeted therapeutic agents for prostate cancer | NSA - Dove Medical Press

The leaders of the 'Quad' nations -- India, Australia, Japan and the United States will hold an in-person summit later this year said the United States National Security Advisor Jake Sullivan on Friday (local time).

Speaking at a White House Press briefing, Sullivan said that the Quad leaders summit -- attended by US President Joe Biden, Australia Prime Minister Scott Morrison, Indian Prime Minister Narendra Modi and Japan Prime Minister Yoshihide Suga -- focussed on the challenges posed by China.

"The four leaders did discuss the challenge posed by China and they made clear that none of them had any allusions about China. Today was not fundamentally about China--much of the focus was on pressing global crises," Sullivan said.

He added, "The leaders also agreed that they would meet in person by the end of the year and they launched a set of working groups including a technology group that would help set standards in key technologies like 5G... The Quad is a critical part of the architecture of the Indo-Pacific and today's summit also kicks of an intensive stretch of diplomacy in the region."

The alliance also discussed the navigation in the East and South China Seas, North Korea as well as the coup in Myanmar were among the numerous topics during the very first meeting at such a level, the adviser added.

"During the meeting, the leaders addressed key regional issues including freedom of navigation and freedom from coercion in the South and East China Seas, the DPRK nuclear issue and the coup and violent repression in Burma," Sullivan said.

"Today is a big day for American diplomacy -- this summit is a big deal for the president and the country. We are looking forward to the work ahead," he added.

During the first Quadrilateral Security Dialogue (Quad), the four leaders - the US, Australia, India and Japan - stressed for a free, open and rule-based Indo-Pacific region that is "anchored by democratic values, and unconstrained by coercion".

In a joint statement, the Quad leaders said: "We bring diverse perspectives and are united in a shared vision for the free and open Indo-Pacific. We strive for a region that is free, open, inclusive, healthy, anchored by democratic values, and unconstrained by coercion."

"Today, the global devastation caused by COVID-19, the threat of climate change, and security challenges facing the region summon us with renewed purpose," they said. The Quad is a strategic forum comprising India, Japan, Australia and the United States of America, held its first-ever head of states meet virtually on Friday.

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Quad leaders to hold in-person summit later this year: US NSA Sullivan - Business Standard

By Udora Orizu

The House of Representatives has asked the office of the National Security Adviser (NSA) and the Ministry of Mines and Steel Development to immediately stop issuing licences to oil serving companies for the importation of explosives.

The Chairman of the House Committee on Mines and Steel Development, Hon. Micheal Enyong Okon, gave the directive in his ruling at an investigative hearing on licencing and sale of explosive devices by chief executives of some oil servicing companies in Nigeria.

He said some companies were not complying with the extant laws, and with the prevailing security situation in the country, there is the need to ascertain the adherence of these companies to extant statutes and regulations on explosives control vis-a-vis the administration and utilisation generally.

The lawmaker said the companies were importing more than authorised, fearing that the explosives could get into the hands of terrorists who may use it against the country.

Okon said: It is important that we educate them on the need to ensure that the administration and utilisation of explosives is in accordance with the Explosives Act of 1967 as contained in the laws of Nigeria. The permit is issued by the Ministry of Mines and Steel, and the end users certificate is also issued by the office of the National Security Adviser (NSA).

The end user certificate would also show the items you brought into the country. You can have less of these products. It is not a problem, but when you have more than what was authorised, what you were allowed in the permit, it therefore means that you are importing these explosives illegally into the country, and that is worrisome, especially in the prevailing security situation in the country. So, we want to know the whereabouts of these explosives. We want to make sure these particular items do not end up in the wrong hands-it can be terrorists, aliens. Thats why we are here to make sure there is a corresponding inventory from the end users.

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Insecurity: House Urges NSA to Stop Issuing Licences for Importation of Explosives - THISDAY Newspapers

By Paul Rosenzweig, Ph.D., The George Washington University Law SchoolTerrorist Investigations Before 9/11

As the 9/11 Commission states, in December 1999, the NSA picked up the movements of Khalid al-Mihdhar, an individual then identified as Nawaf Mihdhar, which linked him to a terrorist facility in the Middle East.

Mihdhar was tracked to Kuala Lumpur, where he met with other then-unidentified individuals. Some photographs were taken of these men on the streets of Kuala Lumpur. The surveillance trailed off when three of them moved on to Bangkok on January 8, 2000. Those pictures became relevant to the FBIs pre-attack criminal investigation in July 2001.

Unfortunately, as the 9/11 Commission found, the NSA reports contained caveats that their contents could not be shared with criminal investigators without the Office of Intelligence Policy Reviews (OIPRs) permission.

Therefore, an FBI intelligence analyst who reviewed the material concluded she could not pass the information contained in these reports to the FBI. She neither asked OIPR for permission to share the reports, nor did she explain to the agents anything about the caveats, only that she could not share the information due to a wall.

And what was this wall? In October 1978, President Jimmy Carter signed into law the FISA legislation that established a new framework for American policy, mandating a strict separation of the CIA and the FBI. In effect, the Congress erected a wall between intelligence gathering and law enforcement.

This is a transcript from the video series The Surveillance State: Big Data, Freedom, and You. Watch it now, on The Great Courses Plus.

The creation of the wall, and rules governing it, erected a compliance culture within the FBI, where failure to follow procedure could result in adverse personnel actions.

The failures of 9/11 were less about statutory language and more about human fears, hesitations, an abundance of caution and the inability of bureaucratic organizations to adapt to discrete circumstances.

Even more than a wall, the law created a spacea dangerous voidbetween the governments criminal and intelligence sides of the house.

Learn more about local police on the cyber beat.

In late September 2001, the executive branch sent to the Congress a draft legislation proposing changes to FISAs certification requirement for electronic surveillance and physical search applications. In the area of foreign intelligence collection, the prescribed change was from the purpose to a purpose.

Associate Deputy Attorney General David Kris testified at a September 24, 2001, hearing on the legislation that the animating purpose of the change was to bring the two sides together; allow for a single unified, cohesive response; and avoid splintering and fragmentation.

Even then, some civil libertarians expressed concern. Critics of the legislation thought that simply requiring that foreign intelligence be a purpose of the collection was too big a blank check for the government to make use of FISA.

As a compromise, the proposed law was changed from the purpose to a significant purpose.

The FISA Court of Review, as an appeals court for the FISA Court itself, summarized the new standard.

It said that the FISA Court should not deny an application if ordinary crimes were inextricably intertwined with foreign intelligence crimes.

So long as foreign intelligence was a realistic option, using the relaxed FISA procedures was acceptable. On the other hand, the review court said the FISA process cannot be used as a device to investigate wholly unrelated ordinary crimes.

Learn more about East Germanys Stasi State.

What all of this demonstrates is the cyclical nature of legislative and judicial branch oversight of national security activities over the course of U.S. history.

The pendulum swings back and forth, over and over again. The CIA, the FBI, and later, the NSA undertook extensive surveillance of Americans during the 1940s, 50s, and 60s. These activities were largely unregulated, hence the response by the legislative and judicial branches was to impose controls.

Congress passed Title III, mandating judicial pre-approval of electronic surveillance; then the Supreme Court decided the Keith Case in 1972, interpreting Title III to extend to domestic security investigations; and then Congress passed FISA in 1978, bringing surveillance activities aimed at foreign intelligence collection under judicial review as well.

A comparable cycle occurred after 9/11. The Bush Administration took the position that the Patriot Act of October 2001 authorized it to frequently task the NSA to conduct warrantless surveillance. Then came public backlash and, later, somewhat greater restrictions.

For now, we can end with a better understanding of why so many voices in the intelligence community were convinced that the government needed to share intelligence information more widely than it had before the 9/11 attacks.

We cannot prove a counterfactual premise that had the FBI possessed the information it was not allowed, the terror attacks would have been averted. But that is our suspicion and so, just like in Berlin a generation earlier, the wall had to come down.

Before 9/11, intelligence was sometimes shared in inappropriate manners like using evidence collected illegally for a criminal case which would lead to the evidence being thrown out.

Before 9/11, the FBI feared using evidence or even asking for authorization. They began being very cautious when it came to handling evidence and this led to criminal and intelligence institutions cooperating less than ever.

After 9/11, many changes were introduced in the system but when it came to FISA, the Congress acted very quickly. They proposed changes to the legislation so as to cover its weak points like when it came to certification requirements for surveillance and physical search.

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The Effects of 9/11 on Intelligence Sharing - The Great Courses Daily News

MANILA, Philippines -- The Association of Boxing Alliances of the Philippines (ABAP) managed to qualify two boxers to the Tokyo Olympics, just before the COVID-19 pandemic shut down the sports world last year.

Middleweight Eumir Marcial and flyweight Irish Magno booked their tickets to the Olympics in the Asia and Oceania Boxing Qualification Tournament in Amman, Jordan, with Marcial even bagging the gold medal in the 75 kg division.

ABAP, headed by President Ricky Vargas, is hopeful that at least two more boxers will secure their spots as well, once the International Olympic Committee Boxing Task Force comes out with its final list of qualified boxers to the Tokyo Games. The final qualification tournament, set in May, had been cancelled due to the pandemic.

The federation is pinning its hopes on flyweight Carlo Paalam and bantamweight Nesthy Petecio, a former world champion, to make it based on their current rankings.

For its consistent work of sending Filipino boxers to the Olympics, ABAP will receive the National Sports Association (NSA) of the Year award in the Philippine Sportswriters Association Awards Night on March 27, to be held virtually.

This is the second straight year that the boxing federation has received the award.

ABAP qualified two boxers in the 2016 Rio De Janeiro Olympics in Rogen Ladon (light flyweight) and Charly Suarez (lightweight), although none of them was able to get past the round-of-16.

This time, the federation hopes to surpass the numbers should Petecio and Paalam make it to the final qualifying list.

But the 25-year-old Marcial looms as boxing's biggest hope for a possible first ever gold medal following his impressive triumph during the Asia-Oceania qualifiers last year.

Now fighting as a pro, the native of Lunzuran, Zamboanga eked out a close 3-2 decision against Abilkhan Amankul of Kazakhstan to win the gold and make it to the Olympics.

The 29-year-old Magno, was not fortunate to make the semifinals of the same tournament in Jordan, but clinched a berth in Tokyo after winning her box-off against Sumaiya Qosimova of Taijikistan, 5-0, to become the first Filipina boxer to reach the Olympics.

Pro golfer Yuka Saso headlines the 2020 honor roll of the country's oldest media organization headed by President Tito S. Talao, sports editor of the Manila Bulletin, as she will be recognized with the prestigious Athlete of the Year honor.

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Philippine Sportswriters Association, PSA Awards Night, ABAP, Association of Boxing Alliances of the Philippines, boxing, Eumir Marcial, Nesthy Petecio, Irish Magno, national sports association

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ABAP named NSA of the year after sending 2 boxers to Tokyo Games - ABS-CBN News