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ZMapp – Wikipedia, the free encyclopedia

ZMapp is an experimental biopharmaceutical drug comprising three chimeric monoclonal antibodies under development as a treatment for Ebola virus disease. The drug was first tested in humans during the 2014 West Africa Ebola virus outbreak, but has not been subjected to a randomized controlled trial to determine whether it works, and whether it is safe enough to allow on the market.

ZMapp is under development as a treatment for Ebola virus disease.[2] It was first used experimentally to treat some people with Ebola virus disease during the 2014 West African Ebola outbreak, but as of August 2014 it had not yet been tested in a clinical trial to support widespread usage in humans; it is not known whether it is effective to treat the disease, nor if it is safe.[3][4][5]

Like intravenous immunoglobulin therapy, ZMapp contains neutralizing antibodies[6] that provide passive immunity to the virus by directly and specifically reacting with it in a "lock and key" fashion.[7]

The drug is composed of three monoclonal antibodies (mAbs) that have been chimerized by genetic engineering.[8] The components are chimeric monoclonal antibody c13C6 from a previously existing antibody cocktail called "MB-003" and two chimeric mAbs from a different antibody cocktail called ZMab, c2G4 and c4G7.[2]

ZMapp is manufactured in the tobacco plant Nicotiana benthamiana in the bioproduction process known as "pharming" by Kentucky BioProcessing, a subsidiary of Reynolds American.[1][9][10]

The composite drug is being developed by Leaf Biopharmaceutical (LeafBio, Inc.), a San Diego based arm of Mapp Biopharmaceutical.[11] LeafBio created ZMapp in collaboration with its parent and Defyrus Inc., each of which had developed its own cocktail of antibodies, called MB-003 and ZMab.

MB-003 is a cocktail of three humanized or humanmouse chimeric mAbs: c13C6, h13F6 and c6D8.[2] A study published in September 2012 found that rhesus macaques infected with Ebola virus (EBOV) survived when receiving MB-003 (mixture of 3 chimeric monoclonal antibodies) one hour after infection. When treated 24 or 48 hours after infection, four of six animals survived and had little to no viremia and few, if any, clinical symptoms.[12]

MB-003 was created by Mapp Biopharmaceutical, based in San Diego, with years of funding from US government agencies including the National Institute of Allergy and Infectious Disease, Biomedical Advanced Research and Development Authority, and the Defense Threat Reduction Agency.[1][13]

ZMAb is a mixture of three mouse mAbs: m1H3, m2G4 and m4G7.[2] A study published in November 2013 found that EBOV-infected macaque monkeys survived after being given a therapy with a combination of three EBOV surface glycoprotein (EBOV-GP)-specific monoclonal antibodies (ZMAb) within 24 hours of infection. The authors concluded that post-exposure treatment resulted in a robust immune response, with good protection for up to 10 weeks and some protection at 13 weeks.[14]

ZMab was created by Defyrus, a Toronto-based biodefense company, funded by the Public Health Agency of Canada.[15] The identification of the optimal components from MB-003 and ZMab was carried out at the Public Health Agency of Canadas National Microbiology Laboratory in Winnipeg.[16]

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wikipedia org boeing 777 – Video


wikipedia org boeing 777

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Boston – Wikipedia, the free encyclopedia

Boston, Massachusetts State capital City of Boston Clockwise: Skyline of Back Bay seen from the Charles River, Fenway Park, Church of Christ, Scientist, Boston Common and the Downtown Crossing skyline, skyline of the Financial District seen from the Boston Harbor, and Massachusetts State House Nickname(s): Beantown,[1] The Hub,[1] The Cradle of Liberty, The Cradle of Modern America,[1] The Athens of America, The Walking City[1] Motto: Sicut patribus sit Deus nobis (Latin: "As God was with our fathers, so may He be with us") Boston (red) is in Suffolk County (gray+red) in the state of Massachusetts Location in the United States Coordinates: 422129N 710349W / 42.35806N 71.06361W / 42.35806; -71.06361Coordinates: 422129N 710349W / 42.35806N 71.06361W / 42.35806; -71.06361 Country United States State Massachusetts County Suffolk Historic countries Kingdom of England Kingdom of Great Britain Historic colonies Massachusetts Bay Colony, Province of Massachusetts Bay Settled (town) September 7, 1630 (date of naming, O.S.) Incorporated (city) March 4, 1822 Government Type Strong mayor council Mayor Marty Walsh (D) Council Boston City Council Area State capital 89.63sqmi (232.14km2) Land 48.42sqmi (125.41km2) Water 41.21sqmi (106.73km2) Urban 1,770sqmi (4,600km2) Metro 4,500sqmi (11,700km2) CSA 10,600sqmi (27,600km2) Elevation 141ft (43m) Population (2013)[4][5][6][7][8] State capital 645,966 [3] Density 13,340/sqmi (5,151/km2) Urban 4,180,000 (US: 10th) Metro 4,590,000 (US: 10th) CSA 7,600,000 (US: 6th) Demonym Bostonian Time zone EST (UTC-5) Summer (DST) EDT (UTC-4) ZIP code(s) 0210802137, 02163, 02196, 02199, 02201, 02203, 02204, 02205, 02206, 02210, 02211, 02212, 02215, 02217, 02222, 02228, 02241, 02266, 02283, 02284, 02293, 02295, 02297, 02298, 02467 (02467 also includes parts of Newton and Brookline) Area code(s) 617 and 857 FIPS code 25-07000 GNIS feature ID 0617565 Website cityofboston.gov

Boston (pronounced i//) is the capital and largest city[10] of the Commonwealth of Massachusetts in the United States. Boston also serves as county seat of Suffolk County. The largest city in New England, the city proper, covering 48 square miles (124km2), had an estimated population of 645,966 in 2014,[11] making it the 24th largest city in the United States.[4] The city is the anchor of a substantially larger metropolitan area called Greater Boston, home to 4.5million people and the tenth-largest metropolitan area in the country.[7] Greater Boston as a commuting region[12] is home to 7.6million people, making it the sixth-largest Combined Statistical Area in the United States.[8][13]

One of the oldest cities in the United States, Boston was founded on the Shawmut Peninsula in 1630 by Puritan colonists from England.[14] It was the scene of several key events of the American Revolution, such as the Boston Massacre, the Boston Tea Party, the Battle of Bunker Hill, and the Siege of Boston. Upon American independence from Great Britain, the city continued to be an important port and manufacturing hub, as well as a center for education and culture. Through land reclamation and municipal annexation, Boston has expanded beyond the original peninsula. Its rich history helps attract many tourists, with Faneuil Hall alone attracting over 20million visitors.[17] Boston's many "firsts" include the United States' first public school, Boston Latin School (1635),[18] and first subway system (1897).

The area's many colleges and universities make Boston an international center of higher education and medicine, and the city is considered to be a world leader in innovation for a variety of reasons.[20][21] Boston's economic base also includes finance,[22] professional and business services, and government activities.[23] The city has one of the highest costs of living in the United States,[24] though it remains high on world livability rankings.[25]

Boston's early European settlers had first called the area Trimountaine (after its "three mountains"only traces of which remain today) but later renamed it Boston after Boston, Lincolnshire, England, from which several prominent colonists had come. The renaming, on September 7, 1630 (old style), was by Puritan colonists from England,[26] who had moved over from Charlestown earlier that year in quest of fresh water. Their settlement was initially limited to the Shawmut Peninsula, at that time surrounded by the Massachusetts Bay and Charles River and connected to the mainland by a narrow isthmus. The peninsula is known to have been inhabited as early as 5000 BC.[27]

In 1629, the Massachusetts Bay Colony's first governor, John Winthrop, led the signing of the Cambridge Agreement, a key founding document of the city. Puritan ethics and their focus on education influenced its early history; America's first public school was founded in Boston in 1635.[18] Over the next 130 years, the city participated in four French and Indian Wars, until the British defeated the French and their native allies in North America. Boston was the largest town in British North America until Philadelphia grew larger in the mid 18th century.[29]

Many of the crucial events of the American Revolutionthe Boston Massacre, the Boston Tea Party, Paul Revere's "midnight ride", the battles of Lexington and Concord and Bunker Hill, the Siege of Boston, and many othersoccurred in or near Boston. After the Revolution, Boston's long seafaring tradition helped make it one of the world's wealthiest international ports, with rum, fish, salt, and tobacco being particularly important.[31]

The Embargo Act of 1807, adopted during the Napoleonic Wars, and the War of 1812 significantly curtailed Boston's harbor activity. Although foreign trade returned after these hostilities, Boston's merchants had found alternatives for their capital investments in the interim. Manufacturing became an important component of the city's economy, and by the mid-19th century, the city's industrial manufacturing overtook international trade in economic importance. Until the early 20th century, Boston remained one of the nation's largest manufacturing centers and was notable for its garment production and leather-goods industries.[32] A network of small rivers bordering the city and connecting it to the surrounding region facilitated shipment of goods and led to a proliferation of mills and factories. Later, a dense network of railroads furthered the region's industry and commerce.

During this period Boston flourished culturally as well, admired for its rarefied literary life and generous artistic patronage,[34][35] with members of old Boston familieseventually dubbed Boston Brahminscoming to be regarded as the nation's social and cultural elites. Boston also became a center of the abolitionist movement.[37] The city reacted strongly to the Fugitive Slave Law of 1850,[38] contributing to President Franklin Pierce's attempt to make an example of Boston after the Anthony Burns Fugitive Slave Case.[39][40]

In 1822,[41] the citizens of Boston voted to change the official name from "the Town of Boston" to "the City of Boston", and on March 4, 1822, the people of Boston accepted the charter incorporating the City.[42] At the time Boston was chartered as a city, the population was about 46,226, while the area of the city was only 4.7 square miles (12km2).[42]

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Wikipedia founder Jimmy Wales on Ayn Rand, art, and making money – Video


Wikipedia founder Jimmy Wales on Ayn Rand, art, and making money
http://www.fordhallforum.org/wales.html Wikipedia founder Jimmy Wales addresses how Objectivist philosophy guides his nonprofit work. (November 1, 2008)

By: Atlas Society

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Wikipedia founder Jimmy Wales on Ayn Rand, art, and making money - Video

Wikipedias Indonesia fail

Hendropriyono. Pic: AP.

Its high time to demiliatarize the Wiki Bahasa version, writes Asia SentinelsWarren Doull

With the great hope for Indonesian democracy, President Joko Jokowi Widodo, taking office last month, pro-democracy groups in the country are buzzing. They are asking that he tend to unresolved injustices like grievances in remote Papua, reconciliation for the bloody 1965 anti-communist purges and the abductions of political activists in 1997-1998.

I have a simpler request, and it goes for Indonesian NGOs and pressure groups also. Bring balance to the Indonesian version of Wikipedia. While it may not always be the most accurate or objective source of information, Wikipedia is certainly a popular source of information. Indeed, the Bahasa version of Wikipedia is approaching one million articles. So the Indonesian public is not well served if articles about certain retired generals and political groups are presented in a one-sided manner in Indonesian.

For example, when it talks about former general AM Hendropriyono, who was a transition team advisor to Jokowi, Wikipedia Bahasa verges on propaganda. So, too, when it talks about East Timor and the separatist Free Papua Movement (OPM).

Wikipedias Indonesian version tells Bahasa Indonesia speakers that, during his early days as a special forces commander, Hendropriyono not only paid attention to the welfare of his soldiers, but also to their discipline. In 1991, Hendropriyono wisely and methodically moved coffee farmers from a protected forest in two sub-districts of Lampung province. It also vaguely notes an incident in Lampung in 1989, when Hendropriyono succeeded in eliminating potential radicalism that was growing in the Talangsari area (berhasil mengeliminasi potensi radikalisme yang tumbuh di kawasan Talangsari). The entry doesnt mention accusations that at least 27 farmers were killed by Hendropriyonos soldiers during this incident.

Nor does the article mention Hendropriyonos suspected involvement in the murder of activist Munir, who died on board a Garuda Indonesia airliner in 2004 after being poisoned. Or his suspected funding of pro-Indonesian militias who murdered over 1000 civilians in East Timor in 1999. The only hint of his controversial past is a revision on Aug. 20, 2014 that says vaguely: Hendropriyono is said to have been connected to a number of human rights violations.

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