was ist da in dieser Admin Wikipedia schon wieder mit Eike Sauer los?
hier prange ich das Allgemeinwissen eines Administrators an. Gut, das kann man auch bei Yahoo Clever, Cosmiq.de oder Gutefrage.net machen, weil da genauso abgnger von Sonderschulen ...
By: besserals juliensblog
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was ist da in dieser Admin Wikipedia schon wieder mit Eike Sauer los? - Video
Jennifer Ann "Jenny" McCarthy (born November 1, 1972)[1][2] is an American model, television host, comedic actress, author, and anti-vaccine activist. She began her career in 1993 as a nude model for Playboy magazine and was later named their Playmate of the Year. McCarthy then parlayed her Playboy fame into a television and film acting career. She was formerly a co-host on the ABC talk show The View.
McCarthy has written books about parenting, and has become an activist promoting research into environmental causes and alternative medical treatments for autism. She has claimed that vaccines cause autism[3] and that chelation therapy helped cure her son of autism.[4][5] Both claims are unsupported by medical consensus, and her son's autism diagnosis has been questioned.[5][6] McCarthy has been described as "the nations most prominent purveyor of anti-vaxxer ideology",[7] but she has denied the charge.[7]
McCarthy was born in Evergreen Park, Illinois, a suburb of Chicago, to a working-class Catholic family, and has Irish, German, and Polish ancestry.[8] She lived in the West Elsdon neighborhood of Chicago.[9][10] She is the second of four daughters; her sisters are named Lynette, Joanne and Amy. Melissa McCarthy is her cousin.[11][12] McCarthy's mother, Linda, was a housewife and courtroom custodian, and her father, Dan McCarthy, was a steel mill foreman.[13][14]
As a teenager, McCarthy attended Mother McAuley Liberal Arts High School (whose school sweater she donned in the pages of Playboy) and was a cheerleader at both Brother Rice High School and St. Laurence High School,[15] although she has referred to herself as an "outcast" at her school[16] and has described how she was repeatedly bullied by classmates.[17]
In 1993, Playboy magazine offered McCarthy $20,000 ($32,651 in 2014 currency) to pose for its October issue. McCarthy became the Playmate of the Month for October 1993. Playboy publisher Hugh Hefner cites McCarthy's "wholesome Catholic girl" persona as the unique quality for which she was selected out of 10,000 applicants.[18][19] Her layout emphasized her Catholic upbringing with a schoolgirl theme. According to McCarthy, the pictorial caused an uproar in her Catholic neighborhood, and resulted in her house being pelted with eggs, her sisters being taunted at school, and McCarthy, who counted Catholic nuns among her aunts, being lectured about her future damnation by those close to her.[18] McCarthy was later made the Playmate of the Year, and was paid a $100,000 salary.[18][19] In 1994, because of her newfound public attention, McCarthy moved to Los Angeles and, for a time, hosted Hot Rocks, a Playboy TV show featuring uncensored music videos.
In 1995, when MTV chose McCarthy to cohost a new dating show called Singled Out, she left Hot Rocks. Her job as a host was a success, and Playboy wanted her to do more modeling. That same year, she also appeared at World Wrestling Federation (WWF) pay-per-view event WrestleMania XI as a guest valet for villain Shawn Michaels, who faced heroic WWF Champion, Diesel. She left after the match with the victor, Diesel. McCarthy returned to World Wrestling Entertainment (WWE, formerly the WWF) on the August 2, 2008 edition of Saturday Night's Main Event to thank the fans for supporting Generation Rescue, an autism advocacy organization. In 1996, she landed a small part in the comedy The Stupids. In 1997, McCarthy launched two shows. The first one was an MTV sketch comedy show The Jenny McCarthy Show, which was sufficiently popular for NBC to sign her for an eponymous sitcom later that year, Jenny. Also in 1997, she appeared on one of two covers for the September issue of Playboy (the other cover featured Pamela Anderson). McCarthy also released an autobiography: Jen-X: Jenny McCarthy's Open Book.[20]
In 1998, McCarthy's first major movie role was alongside Trey Parker and Matt Stone in the comedy BASEketball. The following year, she starred in Diamonds, a movie which was directed by her then-husband John Mallory Asher. In 2000, she had a role in the horror movie Scream 3, and three years later she parodied that role in horror film spoof Scary Movie 3 along with fellow Playmate and actress Pamela Anderson. In 2005, McCarthy produced, wrote, and starred in the movie Dirty Love, where she was again directed by her husband at the time, John Asher. In March 2006, she was given Razzie Awards for "Worst Actress", "Worst Screenplay", and "Worst Picture" for her work on Dirty Love, which also earned Asher a Razzie for "Worst Director."[21]
In addition to her early TV fame on MTV and her short-lived, self-titled NBC sitcom, McCarthy has guest starred in a variety of other television shows including Stacked, Charmed, The Drew Carey Show, Wings, Fastlane, Two and a Half Men and Just Shoot Me!.[citation needed] She was the voice of Six in the third season of Canadian computer-animated science fiction cartoon Tripping the Rift. In 2005, McCarthy hosted a show on E! called Party at the Palms. The reality show, which was filmed at The Palms Hotel in Las Vegas, featured hotel guests, party goers, and celebrities.[22]
McCarthy has continued her work with Playboy over the years, both as a model and in other capacities. She appeared on the cover of the magazine's January 2005 issue wearing a leopard skin version of the company's iconic "bunny suit" and was featured in a pictorial shot at Elvis Presley's Graceland mansion in that same issue. She was the second woman (following Carmen Electra) and first former Playmate to become a celebrity photographer for the Playboy Cyber Club, where she photographed model Jennifer Madden.[citation needed]
Jenny's younger sister Amy has also posed for Playboy. She was Cyber Girl of the Week for September 27, 2004, and Cyber Girl of the Month for January, 2005.[23]
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Jenny McCarthy - Wikipedia, the free encyclopedia
ZMapp is an experimental biopharmaceutical drug comprising three chimeric monoclonal antibodies under development as a treatment for Ebola virus disease. The drug was first tested in humans during the 2014 West Africa Ebola virus outbreak, but has not been subjected to a randomized controlled trial to determine whether it works, and whether it is safe enough to allow on the market.
ZMapp is under development as a treatment for Ebola virus disease.[2] It was first used experimentally to treat some people with Ebola virus disease during the 2014 West African Ebola outbreak, but as of August 2014 it had not yet been tested in a clinical trial to support widespread usage in humans; it is not known whether it is effective to treat the disease, nor if it is safe.[3][4][5]
Like intravenous immunoglobulin therapy, ZMapp contains neutralizing antibodies[6] that provide passive immunity to the virus by directly and specifically reacting with it in a "lock and key" fashion.[7]
The drug is composed of three monoclonal antibodies (mAbs) that have been chimerized by genetic engineering.[8] The components are chimeric monoclonal antibody c13C6 from a previously existing antibody cocktail called "MB-003" and two chimeric mAbs from a different antibody cocktail called ZMab, c2G4 and c4G7.[2]
ZMapp is manufactured in the tobacco plant Nicotiana benthamiana in the bioproduction process known as "pharming" by Kentucky BioProcessing, a subsidiary of Reynolds American.[1][9][10]
The composite drug is being developed by Leaf Biopharmaceutical (LeafBio, Inc.), a San Diego based arm of Mapp Biopharmaceutical.[11] LeafBio created ZMapp in collaboration with its parent and Defyrus Inc., each of which had developed its own cocktail of antibodies, called MB-003 and ZMab.
MB-003 is a cocktail of three humanized or humanmouse chimeric mAbs: c13C6, h13F6 and c6D8.[2] A study published in September 2012 found that rhesus macaques infected with Ebola virus (EBOV) survived when receiving MB-003 (mixture of 3 chimeric monoclonal antibodies) one hour after infection. When treated 24 or 48 hours after infection, four of six animals survived and had little to no viremia and few, if any, clinical symptoms.[12]
MB-003 was created by Mapp Biopharmaceutical, based in San Diego, with years of funding from US government agencies including the National Institute of Allergy and Infectious Disease, Biomedical Advanced Research and Development Authority, and the Defense Threat Reduction Agency.[1][13]
ZMAb is a mixture of three mouse mAbs: m1H3, m2G4 and m4G7.[2] A study published in November 2013 found that EBOV-infected macaque monkeys survived after being given a therapy with a combination of three EBOV surface glycoprotein (EBOV-GP)-specific monoclonal antibodies (ZMAb) within 24 hours of infection. The authors concluded that post-exposure treatment resulted in a robust immune response, with good protection for up to 10 weeks and some protection at 13 weeks.[14]
ZMab was created by Defyrus, a Toronto-based biodefense company, funded by the Public Health Agency of Canada.[15] The identification of the optimal components from MB-003 and ZMab was carried out at the Public Health Agency of Canadas National Microbiology Laboratory in Winnipeg.[16]