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The brewing culture war over vaccine mandates now threatens to boil over after the Biden administration set a January deadline for all employers with more than 100 employees to require shots or regular testing.

Why it matters: The planned mandates which also include even more stringent standards for health care workers would impact more than 100 million Americans, or more than two-thirds of the workforce.

Driving the news: Lawsuits from 15 GOP-led states rolled in mere hours after the administration last week laid out Jan. 4 as the deadline for vaccine mandates at employers with more than 100 workers.

The other side: U.S. Surgeon General Vivek Murthy took to ABC's "This Week" on Sunday to defend the Biden administration's mandate plan as a workplace safety and economic issue.

But, but, but: NFL quarterback Aaron Rodgers took the mantle as a foil to employer vaccine mandates and COVID-19 protocol after it was revealed he was unvaccinated. He'd previously told reporters he was "immunized."

The big picture: A recent Axios-Ipsos poll found six in 10 employed Americans agreed their employer should require COVID vaccinations.

But they do not agree on what should happen for those who don't comply. Support for firing employees was low, at 14%.

Between the lines: As Axios' Jennifer Kingson wrote, employer vaccine mandates have already impacted millions of workers, and rather than leaving in droves most have either decided to get the shot or have taken advantage of wiggle room offered by their employers.

What we're watching: A mandated deadline for about 4 million federal workers coming up on Nov. 22 could give us a glimpse at how the broader mandates may play out.

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Vaccine mandates inflame the culture wars - Axios