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A trio of progressive groups on Thursday endorsed a primary challenger to Rep. Sean Patrick Maloney (D-N.Y.), escalating a campaign of retribution against the man in charge of salvaging House Democrats' majority in November.

Why it matters: Progressives have waged a nationwide effort to take out moderate and establishment incumbents, and Maloney would likely be their highest-profile ouster of the cycle.

Driving the news: On Thursday, a trio of progressive groups the Progressive Change Campaign Committee, New York Progressive Action Network and Democracy for America endorsed state Sen. Alessandra Biaggi in her bid against Maloney.

The backdrop: Maloney stoked anger from the left by running in a redrawn district mostly represented by Rep. Mondaire Jones (D-N.Y.), a progressive freshman who is now running for an open seat in New York City miles away from his home turf.

But, but, but: There are some key differences between Maloney and other progressive targets.

What they're saying: Maloney's allies argue that support from outside left-wing groups will do little to help Biaggi build support for a seat in which she's a relative newcomer.

What to watch for: Maloney has considerable structural advantages, including endorsements from local party leaders and unions, but recent history suggests Biaggi has a fighting chance.

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Progressives turn up the heat on House Democrats' campaign chair - Axios