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Washington (CNN) Hillary Clinton jumped into the political story of the day late on Monday night with a tweet that compared people who deny the power of vaccines to those who question whether the earth is round or the sky is blue.

Clinton is the prohibitive favorite for the Democratic presidential nomination in 2016 and the tweet was seemingly aimed Republican presidential hopefuls who have questioned whether vaccinations should be required and whether they are tied to mental disorders.

Federal health officials have expressed concern over a recent measles outbreak that has been fueled by skepticism among some parents of infant vaccination schedules. Measles is a disease that children a regularly vaccinated against.

The issue has become political, despite the fact that claims like vaccines leading to childhood autism have been debunked by scientific research.

Sen. Rand Paul of Kentucky questioned the safety of vaccines when he said he had "heard of many tragic cases of walking, talking, normal children who wound up with profound mental disorders after vaccines."

"I'm not arguing vaccines are a bad idea. I think they're a good thing. But I think the parents should have some input," he said during an interview on CNBC.

New Jersey Gov. Chris Christie, when asked about the issue, said that he choose to vaccinate his children, but added, "Parents need to have some measure of choice in things as well, so that's the balance that the government has to decide."

Former Hewlett-Packard CEO Carly Fiorina, who is also exploring a 2016 run, told Buzzfeed that while she thinks vaccinating for the measles makes sense, the decisions should be up to the parents.

But renowned neurosurgeon Ben Carson, also a potential Republican presidential candidate, broke from the pack and defended mandatory vaccinations.

"Certain communicable diseases have been largely eradicated by immunization policies in this country and we should not allow those diseases to return by foregoing safe immunization programs, for philosophical, religious or other reasons when we have the means to eradicate them," he told Buzzfeed.

Link:
Hillary Clinton enters vaccination debate, says 'the science is clear'