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"That (the) US arms a terrorist group is what causes instability," Khameini wrote on Twitter Monday. "Who created ISIS? The US!" He added that while US President Donald Trump accuses Iran of supporting terrorists, "terrorism in this region has American roots."

Those attacks, which left at least 12 people dead, were claimed by ISIS.

Qatar's Foreign Minister Mohammed bin Abdulrahman Al Thani said Monday that the country's government still has "no clue what are the main reasons behind all these measures."

"There is no more trust," he said, adding, "it is time for cooler heads to restructure Qatar's approach on foreign policy."

Gulf leaders have also been critical of Qatar's relatively neutral stance on Iran, which they view as a prime destabilizing force in the region.

The diplomatic rift came two weeks after Saudi Arabia, the UAE, Bahrain and Egypt blocked several Qatari media outlets, including Al Jazeera, over comments allegedly made by Qatari Emir Sheikh Tamim bin Hamad Al Thani.

Al Thani reportedly hailed Iran as an "Islamic power" and criticized US President Donald Trump's policy towards Tehran. Qatar said the official news agency which reported the comments was hacked -- and on June 6, US officials told CNN that US investigators believe Russian hackers were behind it.

But al Thani disputed that Monday, saying that "if the problem is Iran, why have those measures been taken against Qatar, why not taken against Iran?"

Al Thani praised French President Emmanuel Macron Monday for being "very active" in attempting to find a "solution to the problem."

British Foreign Secretary Boris Johnson, who is currently in the Gulf for a series of meetings, on Monday "urged all sides (to) refrain from any further escalation and to engage in mediation efforts."

Johnson encouraged Qatar to "take seriously their neighbors' concerns" but also expressed alarm at the blockading of the country and called for it to be eased.

"Qatar is a partner of the UK in the fight against terrorism but they urgently need to do more to address support for extremist groups, building on the steps they have already taken," Johnson said.

CNN's Katie Polglase and Katie Hunt contributed reporting.

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Iran blames US for creating ISIS amid worsening Middle East tensions - CNN