Machine learning may guide use of neoadjuvant therapy for … – Healio
March 22, 2023
2 min read
Chang J, et al. Machine learning-based investigation of prognostic indicators for oncologic outcome of pancreatic ductal adenocarcinoma. Presented at: Society of Surgical Oncology Annual Meeting; March 22-25, 2023; Boston.
Disclosures: Chang reports no relevant financial disclosures. One researcher reports funding from AngioDynamics, Checkmate Pharmaceuticals, Optimum Therapeutics and Regeneron for unrelated projects or clinical trials.
ADD TOPIC TO EMAIL ALERTS
Receive an email when new articles are posted on
Back to Healio
Machine learning algorithms can help predict positive resection margin and lymph node metastases among patients with pancreatic ductal adenocarcinoma, according to study results.
The approach yielded greater positive predictive values than CT scan for both variables, findings presented at Society of Surgical Oncology Annual Meeting showed.
This hopefully can give providers the ability to identify patients with resectable pancreatic cancer who may benefit from neoadjuvant therapies, researcher Jeremy Chang, MD, MS, surgery resident at University of Iowa Hospitals, said during a press conference.
Pancreatic cancer is the third leading cause of cancer-related death, with a disproportionately high mortality rate compared with incidence due to most patients being diagnosed at advanced stages.
Approximately 15% to 20% of cases are deemed curable with surgery, according to study background. However, up to 80% of patients who undergo surgery develop local or distant recurrence, with key risk factors including lymph node metastasis, positive margins after surgery, larger tumor size and no receipt of chemotherapy.
A recent novel notion is there may be patients with resectable tumors at time of diagnosis who would actually benefit from neoadjuvant therapy or chemoradiation before surgery, Chang said. The question now is, how do we find who those patients are?
Chang and colleagues conducted a pilot study to assess the potential of machine learning which uses algorithms to learn and recognize patterns from input data to predict lymph node metastases or positive resection margins from preoperative scans.
Researchers used a 3-D convolutional neural network, optimized to process pixel or image data.
The network can be divided into three segments and 17 layers, Chang said. The first input layer consists of a CT image, followed by 12 layers of feature extraction, and then four layers of classification or output.
The cohort included adults diagnosed with pancreatic ductal adenocarcinoma who underwent pancreatectomy at University of Iowa Hospitals between 2015 and 2021. All patients had viable preoperative CT and postoperative pathology.
The analysis included 79 patients with a combined 480 CT images. The margin portion of the study also included 31 patients with unresectable locally advanced disease who served as positive controls.
Researchers divided patients into a training group which allowed the algorithm to learn and develop its pattern of recognition and a validation group.
The lymph node status portion of the study included a training group of 59 patients with a combined 340 images, and a validation group of 20 patients with a combined 140 images.
Results of a per-patient analysis showed a sensitivity of 100% (95% CI, 80-100) and specificity of 60% (95% CI, 23-93).
Researchers reported a prediction accuracy of 90%, a positive predictive value of 88% (95% CI, 66-88) and a negative predictive value of 100% (95% CI, 44-100).
The margin status portion of the study included a training group of 83 patients with a combined 629 images, as well as a validation group of 27 patients with a combined 252 images.
Results showed a prediction accuracy of 81%, a positive predictive value of 80% (95% CI, 64-98) and a negative predictive value of 82% (95% CI, 59-94).
For context, the positive predictive value of CT scans the most common modality for pancreatic cancer diagnosis and assessment is 73% for identifying positive nodes and 68% for determining whether resection margins will be positive, Chang said.
Future directions for this study will include increasing size of the training and testing cohorts to increase generalizability, Chang said. Were also planning to use this technology to develop a prospective clinical trial to help stratify patients for neoadjuvant treatment.
ADD TOPIC TO EMAIL ALERTS
Receive an email when new articles are posted on
Back to Healio
Read the original:
Machine learning may guide use of neoadjuvant therapy for ... - Healio
- 5 Key Takeaways | The Law of the Machine (Learning): Solving Complex AI Challenges - JD Supra - September 17th, 2025 [September 17th, 2025]
- Spectral and Machine Learning Approach Enhances Efficiency of Grape Embryo Rescue | Newswise - Newswise - September 17th, 2025 [September 17th, 2025]
- Helpful Reminders for Patent Eligibility of AI, Machine Learning, and Other Software-Related Inventions - JD Supra - September 17th, 2025 [September 17th, 2025]
- Opening the black box of machine learning-controlled plasma treatments - AIP.ORG - September 17th, 2025 [September 17th, 2025]
- Post-compilation Circuit Scaling for Quantum Machine Learning Models Reveals Resource Trends and Topology Impacts - Quantum Zeitgeist - September 17th, 2025 [September 17th, 2025]
- Machine-learning tool gives doctors a more detailed 3D picture of fetal health - Medical Xpress - September 17th, 2025 [September 17th, 2025]
- Portable Electronic Nose with Machine Learning Enhances VOC Detection in Forensic Science - Chromatography Online - September 15th, 2025 [September 15th, 2025]
- Developing a predictive model for breast cancer detection using radiomics-based mammography and machine learning - SpringerOpen - September 13th, 2025 [September 13th, 2025]
- and correlation of drug solubility via hybrid machine learning and gradient based optimization - Nature - September 11th, 2025 [September 11th, 2025]
- Rice-Houston Methodist partnership uses machine learning to reveal hidden patient groups in common heart valve disease - Rice University - September 11th, 2025 [September 11th, 2025]
- Amazon Uses Machine Learning to Tell Sellers if FBA Is a Good Fit - EcommerceBytes - September 11th, 2025 [September 11th, 2025]
- Eli Lilly Launches AI, Machine Learning Platform Called TuneLab For Biotech Companies - Stocktwits - September 11th, 2025 [September 11th, 2025]
- How AI and Machine Learning are Shaping the Future of Mobile Apps - indiatechnologynews.in - September 11th, 2025 [September 11th, 2025]
- Hybrid AI and semiconductor approaches for power quality improvement - Machine Learning Week 2025 - September 9th, 2025 [September 9th, 2025]
- The Predictive Turn | Preparing to Outthink Adversaries Through Predictive Analytics - Machine Learning Week 2025 - September 9th, 2025 [September 9th, 2025]
- NFL player props, odds and bets: Week 1, 2025 NFL picks, SportsLine Machine Learning Model AI predictions, SGP - CBS Sports - September 9th, 2025 [September 9th, 2025]
- Can machine learning forecast Lobo EV Technologies Ltd. recovery - Bear Alert & Daily Price Action Insights - Newser - September 6th, 2025 [September 6th, 2025]
- Generalised Machine Learning Models Outperform Personalised Models For Cognitive Load Classification In Real-Life Settings - Frontiers - September 6th, 2025 [September 6th, 2025]
- Machine learning for the prediction of blood transfusion risk during or after mitral valve surgery: a multicenter retrospective cohort study - Nature - September 6th, 2025 [September 6th, 2025]
- Machine Learning-Driven Exploration of Composition- and Temperature-Dependent Transport and Thermodynamic Properties in LiF-NaF-KF Molten Salts for... - September 6th, 2025 [September 6th, 2025]
- Machine learning analysis reveals tumor heterogeneity and stromal-immune niches in breast cancer - Nature - September 6th, 2025 [September 6th, 2025]
- Identification of Postoperative Weight Loss Trajectories and Development of a Machine Learning-Based Tool for Predicting Malnutrition in Gastric... - September 6th, 2025 [September 6th, 2025]
- The Relationship Between Number of Pregnancies and Serum 25-Hydroxyvitamin D Levels in Women with a Prior Pregnancy: A Cross - Sectional Analysis,... - September 6th, 2025 [September 6th, 2025]
- Tohoku University Researchers Use Machine Learning to Identify Factors Improving Nickel-Based Catalysts for CO Methanation - geneonline.com - September 6th, 2025 [September 6th, 2025]
- Combining machine learning predictions for Galaxy Payroll Group Limited - Quarterly Growth Report & AI Forecast Swing Trade Picks - Newser - September 5th, 2025 [September 5th, 2025]
- Can machine learning forecast CLSKW recovery - 2025 Breakouts & Breakdowns & Daily Profit Maximizing Trade Tips - Newser - September 5th, 2025 [September 5th, 2025]
- Can machine learning forecast Granite Real Estate Investment Trust recovery - July 2025 Spike Watch & Growth Focused Stock Reports - Newser - September 5th, 2025 [September 5th, 2025]
- Can machine learning forecast VERU recovery - July 2025 Intraday Action & AI Forecasted Entry/Exit Points - Newser - September 5th, 2025 [September 5th, 2025]
- Can machine learning forecast VCI Global Limited recovery - Market Rally & Expert-Curated Trade Recommendations - Newser - September 5th, 2025 [September 5th, 2025]
- Combining machine learning predictions for AutoNation Inc. - Weekly Trend Summary & Weekly Breakout Watchlists - Newser - September 5th, 2025 [September 5th, 2025]
- Combining machine learning predictions for PLXS - Options Play & Fast Gain Stock Trading Tips - Newser - September 5th, 2025 [September 5th, 2025]
- Can machine learning forecast Valens Semiconductor Ltd. recovery - July 2025 Action & Free Growth Oriented Trading Recommendations - Newser - September 5th, 2025 [September 5th, 2025]
- Improve cost visibility of Machine Learning workloads on Amazon EKS with AWS Split Cost Allocation Data - Amazon Web Services - September 5th, 2025 [September 5th, 2025]
- Can machine learning forecast LFT.PRA recovery - Weekly Trade Recap & Daily Profit Maximizing Trade Tips - Newser - September 5th, 2025 [September 5th, 2025]
- Can machine learning forecast TEAM recovery - 2025 Pullback Review & Free Weekly Chart Analysis and Trade Guides - Newser - September 5th, 2025 [September 5th, 2025]
- Combining machine learning predictions for MSBIP - Weekly Profit Analysis & AI Powered Market Entry Strategies - Newser - September 5th, 2025 [September 5th, 2025]
- Revolutionizing Antibody Discovery with Machine Learning - BIOENGINEER.ORG - September 5th, 2025 [September 5th, 2025]
- The good and bad of machine learning | Letters - The Guardian - September 3rd, 2025 [September 3rd, 2025]
- I'm a machine learning engineer at Amazon who anticipated the ML boom. Here's my advice for staying ahead. - AOL.com - September 3rd, 2025 [September 3rd, 2025]
- Combining machine learning predictions for Dogwood Therapeutics Inc. - July 2025 Breakouts & Weekly Setup with High ROI Potential - Newser - September 3rd, 2025 [September 3rd, 2025]
- Phenotyping valvular heart diseases using the lens of unsupervised machine learning: a scoping review - Nature - September 3rd, 2025 [September 3rd, 2025]
- Students use machine learning to track and protect whale populations - Technology Org - September 3rd, 2025 [September 3rd, 2025]
- Combining machine learning predictions for Triller Group Inc. Equity Warrant - Gap Up & Weekly High Conviction Ideas - Newser - September 3rd, 2025 [September 3rd, 2025]
- Combining machine learning predictions for DallasNews Corporation - Quarterly Trade Report & Technical Entry and Exit Tips - Newser - September 3rd, 2025 [September 3rd, 2025]
- Combining machine learning predictions for System1 Inc. - Weekly Gains Summary & Risk Adjusted Swing Trade Ideas - Newser - September 3rd, 2025 [September 3rd, 2025]
- Unlocking the impossible without compromising on creative control: iZotope Ozone 12 adds new machine learning modules and a more musician-friendly AI... - September 3rd, 2025 [September 3rd, 2025]
- What machine learning models say about SLND.WS - Quarterly Trade Report & Technical Entry and Exit Tips - Newser - September 3rd, 2025 [September 3rd, 2025]
- Combining machine learning predictions for Chemed Corporation - Weekly Stock Recap & Growth Focused Entry Reports - Newser - September 3rd, 2025 [September 3rd, 2025]
- Combining machine learning predictions for TAP.A - Earnings Growth Report & Entry Point Confirmation Alerts - Newser - September 3rd, 2025 [September 3rd, 2025]
- Bridging known and unknown dynamics by transformer-based machine-learning inference from sparse observations - Nature - September 3rd, 2025 [September 3rd, 2025]
- Combining machine learning predictions for Inseego Corp. - July 2025 Retail & Technical Confirmation Trade Alerts - Newser - September 3rd, 2025 [September 3rd, 2025]
- Can machine learning forecast Aditxt Inc. recovery - July 2025 Update & Expert Curated Trade Ideas - Newser - September 3rd, 2025 [September 3rd, 2025]
- I'm a machine learning engineer at Amazon who anticipated the ML boom. Here's my advice for staying ahead. - Business Insider - September 1st, 2025 [September 1st, 2025]
- Machine learning climbs the Jacobs Ladder of optoelectronic properties - Nature - September 1st, 2025 [September 1st, 2025]
- Predicting factors associated with anxiety by patients undergoing treatment for infectious diseases using a random-forest machine learning approach -... - September 1st, 2025 [September 1st, 2025]
- Hideo Kojima used "an AI machine learning rig" to painstakingly download his celebrity friends to Death Stranding 2, but he wasn't happy... - September 1st, 2025 [September 1st, 2025]
- Fibro predict a machine learning risk score for advanced liver fibrosis in the general population using Israeli electronic health records - Nature - September 1st, 2025 [September 1st, 2025]
- Machine learning for preventing stillbirths: is it possible to transform data into life-saving insights? - BMC Pregnancy and Childbirth - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast Kura Sushi USA Inc. recovery - 2025 Fundamental Recap & AI Based Buy and Sell Signals - Newser - September 1st, 2025 [September 1st, 2025]
- Combining machine learning predictions for China Liberal Education Holdings Limited - Weekly Profit Recap & Weekly Breakout Watchlists - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast Tyson Foods Inc. recovery - 2025 Trade Ideas & Smart Swing Trading Techniques - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast GLBZ recovery - July 2025 Movers & AI Based Buy and Sell Signals - Newser - September 1st, 2025 [September 1st, 2025]
- What machine learning models say about Sypris Solutions Inc. - Market Performance Recap & Real-Time Volume Trigger Notifications - Newser - September 1st, 2025 [September 1st, 2025]
- What machine learning models say about Astria Therapeutics Inc. - July 2025 News Drivers & Real-Time Buy Signal Alerts - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast CRTO recovery - July 2025 Analyst Calls & Growth Focused Investment Plans - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast Exelon Corporation recovery - Exit Point & Pattern Based Trade Signal System - Newser - September 1st, 2025 [September 1st, 2025]
- What machine learning models say about OFIX - Bond Market & Long-Term Safe Investment Plans - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast Beneficient recovery - Weekly Trade Recap & Breakout Confirmation Alerts - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast BTBDW recovery - 2025 Geopolitical Influence & Weekly High Momentum Picks - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast Tri Pointe Homes Inc. recovery - July 2025 WrapUp & Free Long-Term Investment Growth Plans - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast TeraWulf Inc. recovery - Market Movement Recap & Community Supported Trade Ideas - Newser - September 1st, 2025 [September 1st, 2025]
- Combining machine learning predictions for Alset Inc. - 2025 Technical Patterns & Precise Buy Zone Identification - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast Exelon Corporation recovery - 2025 Bull vs Bear & Smart Allocation Stock Reports - Newser - September 1st, 2025 [September 1st, 2025]
- Can machine learning forecast Token Cat Limited Depositary Receipt recovery - 2025 Price Action Summary & Breakout Confirmation Alerts - Newser - September 1st, 2025 [September 1st, 2025]
- Combining machine learning predictions for BT Brands Inc. - Market Performance Recap & Verified Technical Trade Signals - Newser - September 1st, 2025 [September 1st, 2025]
- 7 Beginner Machine Learning Projects To Complete This Weekend - KDnuggets - August 29th, 2025 [August 29th, 2025]
- Machine learning approaches for predicting the construction time of drill-and-blast tunnels - Nature - August 29th, 2025 [August 29th, 2025]
- Combining machine learning predictions for KKR.PRD - July 2025 Closing Moves & Technical Pattern Recognition Alerts - Newser - August 29th, 2025 [August 29th, 2025]
- Leveraging data analytics to revolutionize cybersecurity with machine learning and deep learning - Nature - August 29th, 2025 [August 29th, 2025]
- Can machine learning forecast Yext Inc. recovery - Earnings Performance Report & Accurate Buy Signal Notifications - Newser - August 29th, 2025 [August 29th, 2025]