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Sen. Rand Paul (R-Ky.) appeared peeved Thursday when an interviewer at a technology conference asked him to weigh in again on the national debate he helped fuel over vaccines last month.

Thanks for not getting into vaccines, Paul said at the end of a two-minute exchange, eliciting some awkward laughter from a largely conservative crowd at the U.S. Chamber of Commerce headquarters. Im glad we agreed beforehand not to get into that.

The interviewer was self-described libertarian Michael Arrington, who founded the blog TechCrunch.

Arrington said later that he had no agreement with Paul, and that the two were joking. But the exchange at a technology conference underscored how Paul may face a lingering problem on a sensitive issue as he contemplates a presidential run.

You seem convinced that theres a link between autism and vaccines. You didnt actually say that--, Arrington said.

Well I didnt actually say that, Paul interrupted.

Then Arrington read Paul his own controversial quote from an interview he gave last month to CNBC: Ive heard many tragic cases of walking, talking normal children who wound up with profound mental disorders after vaccines.

Paul tried to clarify that quote again, insisting he was misunderstood.

The point is that I have heard of I mean who hasnt ever met a child who has a profound disability and in the parents mind they see a connection, Paul said. But I didnt allege there is a connection. I said I heard of people who believe there is a connection. I do think that vaccines are a good idea. Ive been vaccinated. My kids have been vaccinated.

Paul, an eye doctor, then began a discourse into the history of vaccines and their value in fighting infections. Then Arrington asked if parents should have the right to refuse to vaccinate their children.

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Rand Paul irritated by vaccine questions