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Political commentator and author Ann Coulter arrives at the premiere of "Sharknado 3: Oh Hell No!" at iPic Theaters on July 22.(Photo: Gregg DeGuire, WireImage)

The GOP debate on CNN was full of zingers,but some of the comments that caused the most controversy were from the sidelines.

Conservative syndicated columnist Ann Coulter posted a series of tweets during the GOP debate that many are calling 'anti-semitic." After several candidates addressed the need to strengthen the relationship between the U.S. and Israel, Coulter tweeted, 'How many (expletive) Jews do these people think there are in the United States?"

Coulter, who has over 600,000 followers on Twitter, said she was the responding to the plethora of GOP support for Israeli relations, during the second GOP debate held at the Ronald Reagan Library in California.

Her Twitter tirade began early in the debate and a string of tweets called out the candidates for what she later called "pandering" to Israel.

Coulter received a mixed response, with some offering support and others slamming the columnist as an "anti-semitic." Coulter tweeted in defense of the comments throughout the night.

USA TODAY

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On Twitter Coulter responded to a tweet that said "shame on you," by explaining that she was calling out Republicans for their worn-out rhetoric. She tweeted, "All GOPs = prolife, pro-Reagan, pro-Israel. Pandering on all 3 tonight was EPIC."

On Twitter, the hashtag #IStandWithAnn was used by people voicing support for the columnist.

Others noted that the majority of those using the hashtag were voicing "anti-semitic" opinions.

Follow @Marybowerman on Twitter.

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Ann Coulter rants about 'Jews' and Israel during GOP debate