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Each small step that Science takes to discover how viruses infect cells is always very valuable to researchers and society, since it provides relevant information to fight infections.

However, the recent discovery made by the Ikerbasque Professor Nicola Abrescia, at the Center for Cooperative Research CIC bioGUNE, in collaboration with the University of Helsinki, has been more than just a small step. For the first time, a new mechanism used by viruses to infect cells has been described. This mechanism involves the formation of a tube generated with pre-existing lipids and proteins in the structure of the virus. This study, carried out with a virus model system bacteriophage (infects bacteria) PRD1 leads the way forward in the fight against bacterial infections such as E. coli or Salmonella.

The breakthrough is also very important since the virus that has been analysed is representative of other viruses that infect all the kinds of existing cells: archaea, bacteria and eukaryotic. In other words, they can infect animal and plant cells, bacteria and other types of cells.

Virus with lipid vesicle

Unlike bacteria, which are classified as an independent cell domain, viruses are acellular structures that depend on their ability to infect cells and transfer their genetic material in order to ensure their survival and propagation, as they are not able to reproduce on their own. They are basically composed of a genome (DNA or RNA) and a capsid, in other words, a protein structure that envelopes and protects this genetic material. Some have a lipid vesicle enveloping the capsid and, in other cases, the vesicle is surrounded by the capsid.

Research at the CIC bioGUNE, in collaboration with other European centres, has discovered a new viral phenomenon in which viruses with internal lipid vesicles and specifically bacteriophage PRD1, representative of this virus family, injects its genome into the cell to infect it.

This study has earned its publication in the prestigious scientific journal, PLoS Biology, and has been included as one the most outstanding papers in the Synopsis section. The research team observed how the virus develops a proteolipid tail to create a conductive tube, penetrates the bacterial cell and transfers its genome into it in order to replicate.

Research conclusions

One of the main conclusions of the study is that bacteriophage PRD1 uses the proteins of the membrane in its lipid vesicle and the lipids to assemble the tube. Then it drills a hole in the bacteria, which is an essential step to infect it. Researchers also observed that the tube, one of the smallest that has been studied, only allows the passage of one double-stranded DNA molecule.

Read more here:
Team discovers new form of virus reproduction